| RRC ID |
69162
|
| 著者 |
Nomura T, Nagao K, Shirai R, Gotoh H, Umeda M, Ono K.
|
| タイトル |
Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains.
|
| ジャーナル |
Nat Commun
|
| Abstract |
Ambient temperature significantly affects developmental timing in animals. The temperature sensitivity of embryogenesis is generally believed to be a consequence of the thermal dependency of cellular metabolism. However, the adaptive molecular mechanisms that respond to variations in temperature remain unclear. Here, we report species-specific thermal sensitivity of Notch signaling in the developing amniote brain. Transient hypothermic conditions increase canonical Notch activity and reduce neurogenesis in chick neural progenitors. Increased biosynthesis of phosphatidylethanolamine, a major glycerophospholipid components of the plasma membrane, mediates hypothermia-induced Notch activation. Furthermore, the species-specific thermal dependency of Notch signaling is associated with developmental robustness to altered Notch signaling. Our results reveal unique regulatory mechanisms for temperature-dependent neurogenic potentials that underlie developmental and evolutionary adaptations to a range of ambient temperatures in amniotes.
|
| 巻・号 |
13(1)
|
| ページ |
96
|
| 公開日 |
2022-1-10
|
| DOI |
10.1038/s41467-021-27707-5
|
| PII |
10.1038/s41467-021-27707-5
|
| PMID |
35013223
|
| PMC |
PMC8748702
|
| MeSH |
Animals
Body Temperature / genetics*
Cell Membrane / metabolism
Chick Embryo
Chickens
Embryo, Mammalian
Embryonic Development / genetics*
Gene Expression Regulation, Developmental
Jagged-1 Protein / genetics
Jagged-1 Protein / metabolism
Mice
Mice, Inbred ICR
Neocortex / cytology
Neocortex / growth & development
Neocortex / metabolism*
Neurons / cytology
Neurons / metabolism*
Phosphatidylethanolamines / biosynthesis
Protein Isoforms / genetics
Protein Isoforms / metabolism
Receptor, Notch1 / genetics*
Receptor, Notch1 / metabolism
Signal Transduction / genetics*
Species Specificity
Temperature
Transcription Factor HES-1 / genetics
Transcription Factor HES-1 / metabolism
Turtles
|
| IF |
12.121
|
| リソース情報 |
| ヒト・動物細胞 |
293T(RCB2202) |
