論文 - 詳細
| RRC ID | 69162 |
|---|---|
| 著者 | Nomura T, Nagao K, Shirai R, Gotoh H, Umeda M, Ono K. |
| タイトル | Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains. |
| ジャーナル | Nat Commun |
| Abstract |
Ambient temperature significantly affects developmental timing in animals. The temperature sensitivity of embryogenesis is generally believed to be a consequence of the thermal dependency of cellular metabolism. However, the adaptive molecular mechanisms that respond to variations in temperature remain unclear. Here, we report species-specific thermal sensitivity of Notch signaling in the developing amniote brain. Transient hypothermic conditions increase canonical Notch activity and reduce neurogenesis in chick neural progenitors. Increased biosynthesis of phosphatidylethanolamine, a major glycerophospholipid components of the plasma membrane, mediates hypothermia-induced Notch activation. Furthermore, the species-specific thermal dependency of Notch signaling is associated with developmental robustness to altered Notch signaling. Our results reveal unique regulatory mechanisms for temperature-dependent neurogenic potentials that underlie developmental and evolutionary adaptations to a range of ambient temperatures in amniotes. |
| 巻・号 | 13(1) |
| ページ | 96 |
| 公開日 | 2022-1-10 |
| DOI | 10.1038/s41467-021-27707-5 |
| PII | 10.1038/s41467-021-27707-5 |
| PMID | 35013223 |
| PMC | PMC8748702 |
| MeSH | Animals Body Temperature / genetics* Cell Membrane / metabolism Chick Embryo Chickens Embryo, Mammalian Embryonic Development / genetics* Gene Expression Regulation, Developmental Jagged-1 Protein / genetics Jagged-1 Protein / metabolism Mice Mice, Inbred ICR Neocortex / cytology Neocortex / growth & development Neocortex / metabolism* Neurons / cytology Neurons / metabolism* Phosphatidylethanolamines / biosynthesis Protein Isoforms / genetics Protein Isoforms / metabolism Receptor, Notch1 / genetics* Receptor, Notch1 / metabolism Signal Transduction / genetics* Species Specificity Temperature Transcription Factor HES-1 / genetics Transcription Factor HES-1 / metabolism Turtles |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 18 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293T(RCB2202) |