論文 - 詳細
| RRC ID | 69172 |
|---|---|
| 著者 | Ishiguro KI, Matsuura K, Tani N, Takeda N, Usuki S, Yamane M, Sugimoto M, Fujimura S, Hosokawa M, Chuma S, Ko MSH, Araki K, Niwa H. |
| タイトル | MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells. |
| ジャーナル | Dev Cell |
| Abstract |
The mechanisms regulating meiotic initiation in mammals are enigmatic. It is known that retinoic acid (RA) signaling plays a pivotal role during meiotic initiation. STRA8, which is expressed in response to RA, is thought to be a key factor promoting meiotic initiation. However, the specific role of STRA8 in meiotic initiation has remained elusive. Here, we identified MEIOSIN as a germ-cell-specific factor that associates with STRA8. MEIOSIN, like STRA8, is expressed in response to RA and plays an essential role in meiotic initiation in both males and females. Functional analyses revealed that MEIOSIN acts as a transcription factor together with STRA8, and that both factors are critical for driving meiotic gene activation. Furthermore, temporally restricted expression of MEIOSIN leads to meiotic entry decision during spermatogenesis. The present study demonstrates that MEIOSIN, in collaboration with STRA8, plays a central role in regulating the mitosis to meiosis germ cell fate decision in mammals. |
| 巻・号 | 52(4) |
| ページ | 429-445.e10 |
| 公開日 | 2020-2-24 |
| DOI | 10.1016/j.devcel.2020.01.010 |
| PII | S1534-5807(20)30011-3 |
| PMID | 32032549 |
| MeSH | Adaptor Proteins, Signal Transducing / physiology* Animals Cell Cycle* Cell Differentiation Female Gene Expression Regulation* Germ Cells / cytology Germ Cells / physiology* Male Meiosis* Mice Mice, Inbred C57BL Mice, Knockout Mitosis* Signal Transduction Spermatogenesis Transcription Factors / physiology* |
| IF | 10.092 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 75 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 遺伝子材料 | MEIOSIN-N (RDB) MEIOSIN-C (RDB18713) STRA8-His (RDB18714) STRA8-3xFLAG-HA-P2A-GFP (RDB18715) |