RRC ID |
69199
|
著者 |
Doi M, Morita N, Okuzawa T, Ohgiya S, Okamoto D, Sato K, Ito Y, Matsuura H, Hashidoko Y.
|
タイトル |
Pinellic Acid Isolated from Quercetin-rich Onions has a Peroxisome Proliferator-Activated Receptor-Alpha/Gamma (PPAR-α/γ) Transactivation Activity.
|
ジャーナル |
Planta Med
|
Abstract |
Quercetin, a flavonol, is a functional compound that is abundant in onions and is known to have antioxidant and anti-inflammatory effects. Quercetin and its glucoside are known to function as peroxisome proliferator-activated receptor (PPAR) ligands and showed high PPAR-α transactivation activity but little PPAR-γ transactivation activity in some reports. In this study, we demonstrated that an aqueous extract of a quercetin-rich onion cultivar increased transactivation activities not only of PPAR-α but also of PPAR-γ. We isolated (9S,12S,13S)-(10E)-9,12,13-trihydroxyoctadec-10-enoic acid (pinellic acid) obtained from the aqueous extract using PPAR-γ transactivation as an index. Furthermore, it was revealed that pinellic acid could transactivate PPAR-α. Our findings are the first report mentioned showing that trihydroxyoctadec-10-enoic acids showed PPAR-α/γ transactivation activities.
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巻・号 |
88(6)
|
ページ |
440-446
|
公開日 |
2022-5-1
|
DOI |
10.1055/a-1345-9471
|
PMID |
35038752
|
MeSH |
Fatty Acids, Unsaturated
Onions / metabolism
PPAR alpha / metabolism
PPAR gamma* / metabolism
Quercetin* / pharmacology
Transcriptional Activation
|
IF |
2.687
|
リソース情報 |
ヒト・動物細胞 |
CV-1(RCB0160) |