論文 - 詳細
| RRC ID | 69596 |
|---|---|
| 著者 | Hoshi H, Saito H, Iijima H, Uchida M, Wada T, Ito G, Tanaka H, Sawada T, Hirakawa K. |
| タイトル | Anti-protein-bound polysaccharide-K monoclonal antibody binds the active structure and neutralizes direct antitumor action of the compound. |
| ジャーナル | Oncol Rep |
| Abstract |
Protein-bound polysaccharide K (PSK) is extracted and purified from Coriolus versicolor (CM101), and is used as an anti-cancer agent. In this study, focusing on the direct actions of PSK, we investigated whether PSK reaches tumor and immune tissues with its active structure remaining intact, and the direct action of PSK was evaluated by its antitumor effects against MethA fibrosarcomas implanted in immunodeficient NOD/SCID mice. The results obtained suggest that PSK reaches the tumor tissue in its active form and exhibits antitumor effects against MethA cells. |
| 巻・号 | 25(4) |
| ページ | 905-13 |
| 公開日 | 2011-4-1 |
| DOI | 10.3892/or.2011.1155 |
| PMID | 21249323 |
| MeSH | Animals Antibodies, Anti-Idiotypic / therapeutic use* Antibodies, Monoclonal / therapeutic use* Antineoplastic Agents / therapeutic use* Blotting, Western Enzyme-Linked Immunosorbent Assay Female Fibrosarcoma / immunology Fibrosarcoma / therapy* Mice Mice, Inbred BALB C Mice, Inbred NOD Mice, SCID Proteoglycans / immunology Proteoglycans / therapeutic use* Tumor Cells, Cultured |
| IF | 3.417 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | J774.1(RCB0434) |