論文 - 詳細
| RRC ID | 69623 |
|---|---|
| 著者 | Trianto A, Hermawan I, de Voogd NJ, Tanaka J. |
| タイトル | Halioxepine, a new meroditerpene from an Indonesian sponge Haliclona sp. |
| ジャーナル | Chem Pharm Bull (Tokyo) |
| Abstract |
Chemical investigations on a sponge Haliclona sp. found a meroditerpene 1 having a new carbon skeleton. By analyzing spectroscopic data, the structure was elucidated to comprise a substituted hydroquinone, a tetrahydrooxepine, and a cyclohexene, and these components were united with C1 and C2 units. Compound 1 showed moderate cytotoxicity against NBT-T2 cells with IC50 4.8 µg/ml and also antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 3.2 µg/ml. |
| 巻・号 | 59(10) |
| ページ | 1311-3 |
| 公開日 | 2011-1-1 |
| DOI | 10.1248/cpb.59.1311 |
| PII | JST.JSTAGE/cpb/59.1311 |
| PMID | 21963646 |
| MeSH | Animals Antineoplastic Agents / analysis Antineoplastic Agents / chemistry* Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology Biological Factors Cell Line, Tumor Diterpenes / analysis Diterpenes / chemistry* Diterpenes / isolation & purification Diterpenes / pharmacology Drug Evaluation, Preclinical Drug Screening Assays, Antitumor Haliclona / chemistry* Molecular Structure Stereoisomerism |
| IF | 1.416 |
| リソース情報 | |
| ヒト・動物細胞 | NBT-T2(RCB1370) |