| RRC ID |
69631
|
| 著者 |
Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H.
|
| タイトル |
Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1).
|
| ジャーナル |
ACS Chem Biol
|
| Abstract |
Glutathione peroxidase 4 (GPX4) is an intracellular enzyme that oxidizes glutathione while reducing lipid peroxides and is a promising target for cancer therapy. To date, several GPX4 inhibitors have been reported to exhibit cytotoxicity against cancer cells. However, some cancer cells are less sensitive to the known GPX4 inhibitors. This study aimed to explore compounds showing synergistic effects with GPX4 inhibitors. We screened a chemical library and identified a compound named NPD4928, whose cytotoxicity was enhanced in the presence of a GPX4 inhibitor. Furthermore, we identified ferroptosis suppressor protein 1 as its target protein. The results indicate that NPD4928 enhanced the sensitivity of various cancer cells to GPX4 inhibitors, suggesting that the combination might have therapeutic potential via the induction of ferroptosis.
|
| 巻・号 |
17(2)
|
| ページ |
483-491
|
| 公開日 |
2022-2-18
|
| DOI |
10.1021/acschembio.2c00028
|
| PMID |
35128925
|
| MeSH |
Ferroptosis*
Glutathione / metabolism
Oxidation-Reduction
Phospholipid Hydroperoxide Glutathione Peroxidase
Small Molecule Libraries / pharmacology
|
| IF |
4.434
|
| リソース情報 |
| ヒト・動物細胞 |
A549
MKN74(RCB1002)
PANC-1(RCB2095)
MIA Paca2(RCB2094) |
