RRC ID |
6969
|
著者 |
Miyashita NT, Yoshida K, Ishii T.
|
タイトル |
DNA variation in the metallothionein genes in wild rice Oryza rufipogon: relationship between DNA sequence polymorphism, codon bias and gene expression.
|
ジャーナル |
Genes Genet Syst
|
Abstract |
This study examines the relationship between DNA sequence variation and level of gene expression in four metallothionein genes from wild rice Oryza rufipogon. The nucleotide diversity was 0.0028 to 0.0117 over the entire coding and non-coding region, and it was negatively correlated with gene expression for three type 2 metallothionein genes. In contrast, codon bias and percent of preferred codons correlated positively with gene expression. These results indicate that the intensity of natural selection depends on the level of gene expression, which in turn shapes the level of nucleotide polymorphism. In addition, significant linkage disequilibria were frequent between the metallothionein genes, although significance was not confirmed after multiple test correction. This result suggests that metallothionein genes expressed at different levels are epistatic with respect to fitness, and that gene expression is an important factor determining level of DNA polymorphism.
|
巻・号 |
80(3)
|
ページ |
173-83
|
公開日 |
2005-6-1
|
DOI |
10.1266/ggs.80.173
|
PII |
JST.JSTAGE/ggs/80.173
|
PMID |
16172530
|
MeSH |
Amino Acid Sequence
Asia
Base Sequence
Cluster Analysis
Codon / genetics*
Epistasis, Genetic
Gene Components
Gene Expression*
Genetic Variation*
Linkage Disequilibrium
Metallothionein / genetics*
Metallothionein / metabolism
Molecular Sequence Data
Oryza / genetics*
Phylogeny*
Selection, Genetic
Sequence Analysis, DNA
|
IF |
0.917
|
引用数 |
8
|
WOS 分野
|
GENETICS & HEREDITY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
リソース情報 |
イネ |
W0108
W0593
W0120
W0149
W0630
W1956
W1962
W1964
W1965
W1967
W1972
W1976
W0607 |