RRC ID 6969
著者 Miyashita NT, Yoshida K, Ishii T.
タイトル DNA variation in the metallothionein genes in wild rice Oryza rufipogon: relationship between DNA sequence polymorphism, codon bias and gene expression.
ジャーナル Genes Genet Syst
Abstract This study examines the relationship between DNA sequence variation and level of gene expression in four metallothionein genes from wild rice Oryza rufipogon. The nucleotide diversity was 0.0028 to 0.0117 over the entire coding and non-coding region, and it was negatively correlated with gene expression for three type 2 metallothionein genes. In contrast, codon bias and percent of preferred codons correlated positively with gene expression. These results indicate that the intensity of natural selection depends on the level of gene expression, which in turn shapes the level of nucleotide polymorphism. In addition, significant linkage disequilibria were frequent between the metallothionein genes, although significance was not confirmed after multiple test correction. This result suggests that metallothionein genes expressed at different levels are epistatic with respect to fitness, and that gene expression is an important factor determining level of DNA polymorphism.
巻・号 80(3)
ページ 173-83
公開日 2005-6-1
DOI 10.1266/ggs.80.173
PII JST.JSTAGE/ggs/80.173
PMID 16172530
MeSH Amino Acid Sequence Asia Base Sequence Cluster Analysis Codon / genetics* Epistasis, Genetic Gene Components Gene Expression* Genetic Variation* Linkage Disequilibrium Metallothionein / genetics* Metallothionein / metabolism Molecular Sequence Data Oryza / genetics* Phylogeny* Selection, Genetic Sequence Analysis, DNA
IF 0.917
引用数 8
WOS 分野 GENETICS & HEREDITY BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
イネ W0108 W0593 W0120 W0149 W0630 W1956 W1962 W1964 W1965 W1967 W1972 W1976 W0607