| RRC ID |
69823
|
| 著者 |
Xie Z, Meng J, Kong W, Wu Z, Lan F, Narengaowa, Hayashi Y, Yang Q, Bai Z, Nakanishi H, Qing H, Ni J.
|
| タイトル |
Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer's disease.
|
| ジャーナル |
Aging Cell
|
| Abstract |
Regulation of neuroinflammation and β-amyloid (Aβ) production are critical factors in the pathogenesis of Alzheimer's disease (AD). Cathepsin E (CatE), an aspartic protease, is widely studied as an inducer of growth arrest and apoptosis in several types of cancer cells. However, the function of CatE in AD is unknown. In this study, we demonstrated that the ablation of CatE in human amyloid precursor protein knock-in mice, called APPNL-G-F mice, significantly reduced Aβ accumulation, neuroinflammation, and cognitive impairments. Mechanistically, microglial CatE is involved in the secretion of soluble TNF-related apoptosis-inducing ligand, which plays an important role in microglia-mediated NF-κB-dependent neuroinflammation and neuronal Aβ production by beta-site APP cleaving enzyme 1. Furthermore, cannula-delivered CatE inhibitors improved memory function and reduced Aβ accumulation and neuroinflammation in AD mice. Our findings reveal that CatE as a modulator of microglial activation and neurodegeneration in AD and suggest CatE as a therapeutic target for AD by targeting neuroinflammation and Aβ pathology.
|
| 巻・号 |
21(3)
|
| ページ |
e13565
|
| 公開日 |
2022-3-1
|
| DOI |
10.1111/acel.13565
|
| PMID |
35181976
|
| PMC |
PMC8920437
|
| MeSH |
Alzheimer Disease* / pathology
Amyloid beta-Peptides* / metabolism
Amyloid beta-Protein Precursor / genetics
Amyloid beta-Protein Precursor / metabolism
Animals
Cathepsin E / genetics
Cathepsin E / metabolism
Disease Models, Animal
Mice
Mice, Inbred C57BL
Mice, Transgenic
Microglia / metabolism
Neuroinflammatory Diseases
|
| IF |
7.238
|
| リソース情報 |
| 実験動物マウス |
RBRC06344 |
| ヒト・動物細胞 |
MG6(RCB2403) |
