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  • Search Condition : Filter (MeSH = Amyloid beta-Protein Precursor / genetics)
Species Resource
DNA material pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393) , CSII-CMV-MCS (RDB04377). FBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis.
Human and Animal Cells Restoration of spatial memory dysfunction of human APP transgenic mice by transplantation of neuronal precursors derived from human iPS cells.
Human and Animal Cells Atg5^(+/+)MEF (RCB2710) Atg5^(-/-)MEF (RCB2711) A small-molecule enhancer of autophagy decreases levels of Abeta and APP-CTF via Atg5-dependent autophagy pathway.
C.elegans ? Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors.
DNA material APP cDNA (AZ-10) Amyloid beta protein precursor is involved in the growth of human colon carcinoma cell in vitro and in vivo.
DNA material pco12 EGFR (RDB01276) Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner.
Human and Animal Cells COS-7(RCB0539) TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes.
DNA material pTU1-PalphaAPP (RDB08714) O-Mannosylation is required for the solubilization of heterologously expressed human beta-amyloid precursor protein in Saccharomyces cerevisiae.
Human and Animal Cells MG6(RCB2403) Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice.
Human and Animal Cells 201B7(HPS0063) Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.
C.elegans tm1961 , tm474 Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson's disease, Alzheimer's disease and autism spectrum disorder.
C.elegans tm2034 Toxic role of K+ channel oxidation in mammalian brain.
Drosophila FoxO mediates APP-induced AICD-dependent cell death.