Reference - Detail
| RRC ID | 69888 |
|---|---|
| Author | Jackson SM, Demer LL. |
| Title | Peroxisome proliferator-activated receptor activators modulate the osteoblastic maturation of MC3T3-E1 preosteoblasts. |
| Journal | FEBS Lett |
| Abstract |
The reduced bone mineral density (BMD) observed in osteoporosis results, in part, from reduced activity of bone-forming osteoblasts. We examined the effect of peroxisome proliferator-activated receptor (PPAR) activators on MC3T3-E1 preosteoblast maturation. Activators of PPARalpha, delta and gamma induced alkaline phosphatase activity, matrix calcification and the expression of osteoblast genes as determined by reverse transcriptase-polymerase chain reaction. However, at relatively high concentrations of the specific PPARgamma ligands, ciglitazone and troglitazone, maturation was inhibited. PPARalpha, delta and gamma1 were expressed in MC3T3-E1 cells. PPARgamma1 mRNA and protein levels were induced early during osteoblastic maturation. We speculate that endogenous and pharmacological PPAR activators may affect BMD by modulating osteoblastic maturation. |
| Volume | 471(1) |
| Pages | 119-24 |
| Published | 2000-4-7 |
| DOI | 10.1016/s0014-5793(00)01372-7 |
| PII | S0014-5793(00)01372-7 |
| PMID | 10760525 |
| MeSH | Animals Bone Density / drug effects Cell Differentiation / drug effects Cells, Cultured Humans Mice Osteoblasts / cytology Osteoblasts / drug effects Osteoblasts / metabolism* Protein Isoforms / genetics Protein Isoforms / metabolism RNA, Messenger / metabolism Receptors, Cytoplasmic and Nuclear / genetics Receptors, Cytoplasmic and Nuclear / metabolism* Thiazoles / pharmacology Thiazolidinediones* Transcription Factors / genetics Transcription Factors / metabolism* Transfection |
| IF | 3.057 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 10 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | MC3T3-E1(RCB1126) |