論文 - 詳細
| RRC ID | 69896 |
|---|---|
| 著者 | Ono A, Hattori S, Kariya R, Iwanaga S, Taura M, Harada H, Suzu S, Okada S. |
| タイトル | Comparative study of human hematopoietic cell engraftment into BALB/c and C57BL/6 strain of rag-2/jak3 double-deficient mice. |
| ジャーナル | J Biomed Biotechnol |
| Abstract |
Immunodeficient mice are becoming invaluable tools in human stem cell and tumor research. In this study, we generated Rag-2/Jak3 double-deficient (Rag-2⁻/⁻Jak3⁻/⁻) mice with a C57/BL6 and Balb/c genetic background and compared the human lymphohematopoietic cell engraftment rate. Human cord blood-derived CD34+ hematopoietic stem cells were successfully engrafted into Balb/c Rag-2⁻/⁻Jak3⁻/⁻ mice; however, the engraftment rate was far lower in C57/BL6 Rag-2⁻/⁻Jak3⁻/⁻ mice. Transplantation of human peripheral blood mononuclear cells resulted in the same tendency. Thus, a Balb/c background offers superior engraftment capacity than a C57/BL6 background and provides an attractive model for human hematopoietic cell engraftment. |
| 巻・号 | 2011 |
| ページ | 539748 |
| 公開日 | 2011-1-1 |
| DOI | 10.1155/2011/539748 |
| PMID | 21331358 |
| PMC | PMC3035318 |
| MeSH | Animals Antigens, CD34 / biosynthesis Antigens, CD34 / immunology DNA-Binding Proteins / deficiency* DNA-Binding Proteins / genetics* DNA-Binding Proteins / immunology Flow Cytometry Hematopoietic Stem Cell Transplantation* Hematopoietic Stem Cells / immunology Humans Janus Kinase 3 / deficiency* Janus Kinase 3 / genetics* Janus Kinase 3 / immunology K562 Cells Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout |
| IF | 1.785 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | K562 |