RRC ID 69920
著者 Natsume N, Ozaki K, Nakajima D, Yokoshima S, Teruya T.
タイトル Structure-Activity Relationship Study of Majusculamides A and B and Their Analogues on Osteogenic Activity.
ジャーナル J Nat Prod
Abstract We discovered that majusculamide A (1) and majusculamide B (2), isolated from a marine cyanobacterium collected in Okinawa, induced osteoblast differentiation in MC3T3-E1 cells. Although majusculamide A (1) has a different configuration only at the C-19 stereocenter, bearing a methyl group, compared to majusculamide B (2), the effect of 1 was stronger than that of 2. We synthesized some analogues of the majusculamides (3-15) and evaluated osteogenic activities of these analogues. The structure-activity relationship study of majusculamide analogues suggested that the number of methyls and configuration at C-19 and the nature of the substituent at C-20 of majusculamide A (1) may be important for the osteoblast differentiation-inducing effect of 1.
巻・号 83(8)
ページ 2477-2482
公開日 2020-8-28
DOI 10.1021/acs.jnatprod.0c00441
PMID 32786886
MeSH 3T3 Cells Animals Cell Differentiation / drug effects Mice Osteogenesis / drug effects* Structure-Activity Relationship
IF 3.782
リソース情報
ヒト・動物細胞 MC3T3-E1(RCB1126)