論文 - 詳細
| RRC ID | 69920 |
|---|---|
| 著者 | Natsume N, Ozaki K, Nakajima D, Yokoshima S, Teruya T. |
| タイトル | Structure-Activity Relationship Study of Majusculamides A and B and Their Analogues on Osteogenic Activity. |
| ジャーナル | J Nat Prod |
| Abstract |
We discovered that majusculamide A (1) and majusculamide B (2), isolated from a marine cyanobacterium collected in Okinawa, induced osteoblast differentiation in MC3T3-E1 cells. Although majusculamide A (1) has a different configuration only at the C-19 stereocenter, bearing a methyl group, compared to majusculamide B (2), the effect of 1 was stronger than that of 2. We synthesized some analogues of the majusculamides (3-15) and evaluated osteogenic activities of these analogues. The structure-activity relationship study of majusculamide analogues suggested that the number of methyls and configuration at C-19 and the nature of the substituent at C-20 of majusculamide A (1) may be important for the osteoblast differentiation-inducing effect of 1. |
| 巻・号 | 83(8) |
| ページ | 2477-2482 |
| 公開日 | 2020-8-28 |
| DOI | 10.1021/acs.jnatprod.0c00441 |
| PMID | 32786886 |
| MeSH | 3T3 Cells Animals Cell Differentiation / drug effects Mice Osteogenesis / drug effects* Structure-Activity Relationship |
| IF | 3.782 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |