RRC ID |
69920
|
著者 |
Natsume N, Ozaki K, Nakajima D, Yokoshima S, Teruya T.
|
タイトル |
Structure-Activity Relationship Study of Majusculamides A and B and Their Analogues on Osteogenic Activity.
|
ジャーナル |
J Nat Prod
|
Abstract |
We discovered that majusculamide A (1) and majusculamide B (2), isolated from a marine cyanobacterium collected in Okinawa, induced osteoblast differentiation in MC3T3-E1 cells. Although majusculamide A (1) has a different configuration only at the C-19 stereocenter, bearing a methyl group, compared to majusculamide B (2), the effect of 1 was stronger than that of 2. We synthesized some analogues of the majusculamides (3-15) and evaluated osteogenic activities of these analogues. The structure-activity relationship study of majusculamide analogues suggested that the number of methyls and configuration at C-19 and the nature of the substituent at C-20 of majusculamide A (1) may be important for the osteoblast differentiation-inducing effect of 1.
|
巻・号 |
83(8)
|
ページ |
2477-2482
|
公開日 |
2020-8-28
|
DOI |
10.1021/acs.jnatprod.0c00441
|
PMID |
32786886
|
MeSH |
3T3 Cells
Animals
Cell Differentiation / drug effects
Mice
Osteogenesis / drug effects*
Structure-Activity Relationship
|
IF |
3.782
|
リソース情報 |
ヒト・動物細胞 |
MC3T3-E1(RCB1126) |