| RRC ID |
6999
|
| 著者 |
Kondo S, Xiao JZ, Satoh T, Odamaki T, Takahashi S, Sugahara H, Yaeshima T, Iwatsuki K, Kamei A, Abe K.
|
| タイトル |
Antiobesity effects of Bifidobacterium breve strain B-3 supplementation in a mouse model with high-fat diet-induced obesity.
|
| ジャーナル |
Biosci Biotechnol Biochem
|
| Abstract |
The aim of the present study was to evaluate the anti-obesity activity of a probiotic bifidobacterial strain in a mouse model with obesity induced by a high-fat diet. The mice were fed a high-fat diet supplemented with Bifidobacterium breve B-3 at 10(8) or 10(9) CFU/d for 8 weeks. B. breve B-3 supplementation dose-dependently suppressed the accumulation of body weight and epididymal fat, and improved the serum levels of total cholesterol, fasting glucose and insulin. The bifidobacterial counts in the caecal contents and feces were significantly increased with the B. breve B-3 administration. The expression of genes related to fat metabolism and insulin sensitivity in the gut and epididymal fat tissue was up-regulated by this administration. These results suggest that the use of B. breve B-3 would be effective in reducing the risk of obesity.
|
| 巻・号 |
74(8)
|
| ページ |
1656-61
|
| 公開日 |
2010-1-1
|
| DOI |
10.1271/bbb.100267
|
| PII |
JST.JSTAGE/bbb/100267
|
| PMID |
20699581
|
| MeSH |
Adipose Tissue / metabolism
Adipose Tissue / microbiology
Administration, Oral
Animals
Bifidobacterium / physiology*
Cecum / microbiology
Dietary Fats / adverse effects*
Disease Models, Animal
Epididymis / microbiology
Feces / microbiology
Gene Expression Regulation / drug effects
Insulin Resistance
Intestinal Mucosa / metabolism
Intestines / microbiology
Lipid Metabolism / genetics
Male
Metagenome
Mice
Mice, Inbred C57BL
Obesity / etiology*
Obesity / immunology
Obesity / metabolism
Obesity / microbiology*
Probiotics / administration & dosage
Probiotics / pharmacology*
RNA, Messenger / genetics
RNA, Messenger / metabolism
Serologic Tests
|
| IF |
1.516
|
| 引用数 |
115
|
|
WOS 分野
|
FOOD SCIENCE & TECHNOLOGY
CHEMISTRY, APPLIED
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| 一般微生物 |
JCM 11019
JCM 1131 |
