論文 - 詳細
| RRC ID | 70009 |
|---|---|
| 著者 | Fang J, Li B, Chen LJ, Dogra V, Luo S, Wu W, Wang P, Hwang I, Li HM, Kim C. |
| タイトル | TIC236 gain-of-function mutations unveil the link between plastid division and plastid protein import. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
SignificanceAlthough plastid division is critical for plant development, how components of the plastid division machinery (PDM) are imported into plastids remains unexplored. A forward genetic screen to identify suppressors of a crumpled leaf (crl) mutant deficient in plastid division led us to find dominant gain-of-function (GF) mutations in TIC236, which significantly increases the import of PDM components and completely rescues crl phenotypes. The defective plastid division phenotypes in crl and tic236-knockdown mutants and CRL-TIC236 association in a functional complex indicate that the CRL-TIC236 module is vital for plastid division. Hence, we report the first GF translocon mutants and unveil CRL as a novel functional partner of TIC236 for PDM import. |
| 巻・号 | 119(11) |
| ページ | e2123353119 |
| 公開日 | 2022-3-15 |
| DOI | 10.1073/pnas.2123353119 |
| PMID | 35275795 |
| PMC | PMC8931380 |
| MeSH | Arabidopsis* / cytology Arabidopsis* / genetics Arabidopsis* / metabolism Arabidopsis Proteins* / genetics Arabidopsis Proteins* / metabolism Cell Division* Chloroplast Proteins* / genetics Chloroplast Proteins* / metabolism Gain of Function Mutation Membrane Transport Proteins* / genetics Membrane Transport Proteins* / metabolism Plastids* / genetics Plastids* / metabolism Protein Transport |
| IF | 9.412 |
| リソース情報 | |
| シロイヌナズナ / 植物培養細胞・遺伝子 | pst00216 |