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  • Search Condition : Filter (MeSH = Gain of Function Mutation)
Species Resource Title
Human and Animal Cells HUDEP-2(RCB4557) A novel gain-of-function PIP4K2A mutation elevates the expression of β-globin and aggravates the severity of α-thalassemia.
Human and Animal Cells ME-180(RCB2160) , Ca Ski(RCB1947) Targeting the mutant PIK3CA gene by DNA-alkylating pyrrole-imidazole polyamide in cervical cancer.
Arabidopsis / Cultured plant cells, genes pst00216 TIC236 gain-of-function mutations unveil the link between plastid division and plastid protein import.
C.elegans tm5030 , tm6659 Mutation of daf-2 extends lifespan via tissue-specific effectors that suppress distinct life-limiting pathologies.
C.elegans tm2235 Synaptic Protein Degradation Controls Sexually Dimorphic Circuits through Regulation of DCC/UNC-40.
C.elegans tm783 ROS regulation of RAS and vulva development in Caenorhabditis elegans.
C.elegans tm1036 The Snail transcription factor CES-1 regulates glutamatergic behavior in C. elegans.
Human and Animal Cells Li-7(RCB1941) TBX3 functions as a tumor suppressor downstream of activated CTNNB1 mutants during hepatocarcinogenesis.
Drosophila The Clathrin adaptor AP-1 and Stratum act in parallel pathways to control Notch activation in Drosophila sensory organ precursors cells.
C.elegans tm4533 The hypoxia-response pathway modulates RAS/MAPK-mediated cell fate decisions in Caenorhabditis elegans.
C.elegans tm1227 , tm294 Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei.
C.elegans tm776 Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration.
C.elegans tm3464 Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes.