論文 - 詳細
| RRC ID | 7001 |
|---|---|
| 著者 | Watanabe J, Fujiwara R, Sasajima N, Ito S, Sonoyama K. |
| タイトル | Administration of antibiotics during infancy promoted the development of atopic dermatitis-like skin lesions in NC/Nga mice. |
| ジャーナル | Biosci Biotechnol Biochem |
| Abstract |
This study aimed to determine whether oral antibiotic administration during infancy is associated with the spontaneous development of atopic dermatitis-like skin lesions by modulating intestinal microbiota. Female NC/Nga mice at 3 weeks of age were orally administered kanamycin or polymyxin B. Clinical symptoms, scratching behavior, and serum antibody levels were evaluated. Changes in intestinal microbiota were determined by culture-independent analysis and cultural analysis. The kanamycin-treated mice showed higher clinical scores and scratching frequency than the control mice. IgE levels were significantly higher in the kanamycin-treated mice than in the control mice. Transient changes in intestinal microbiota were observed under kanamycin treatment. Polymyxin B treatment failed to affect scratching behavior. These results suggest that oral administration of kanamycin during infancy promoted the development of atopic dermatitis-like skin lesions in NC/Nga mice and was associated with a transient change in intestinal microbiota. |
| 巻・号 | 74(2) |
| ページ | 358-63 |
| 公開日 | 2010-1-1 |
| DOI | 10.1271/bbb.90709 |
| PII | JST.JSTAGE/bbb/90709 |
| PMID | 20139606 |
| MeSH | Administration, Oral Animals Anti-Bacterial Agents / administration & dosage Anti-Bacterial Agents / adverse effects* Dermatitis, Atopic / pathology* Female Immunoglobulin E / blood Mice Mice, Inbred Strains Pruritus / pathology Severity of Illness Index Skin / pathology* |
| IF | 1.516 |
| 引用数 | 15 |
| WOS 分野 | FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 一般微生物 | JCM 1717 |