RRC ID 7001
著者 Watanabe J, Fujiwara R, Sasajima N, Ito S, Sonoyama K.
タイトル Administration of antibiotics during infancy promoted the development of atopic dermatitis-like skin lesions in NC/Nga mice.
ジャーナル Biosci Biotechnol Biochem
Abstract This study aimed to determine whether oral antibiotic administration during infancy is associated with the spontaneous development of atopic dermatitis-like skin lesions by modulating intestinal microbiota. Female NC/Nga mice at 3 weeks of age were orally administered kanamycin or polymyxin B. Clinical symptoms, scratching behavior, and serum antibody levels were evaluated. Changes in intestinal microbiota were determined by culture-independent analysis and cultural analysis. The kanamycin-treated mice showed higher clinical scores and scratching frequency than the control mice. IgE levels were significantly higher in the kanamycin-treated mice than in the control mice. Transient changes in intestinal microbiota were observed under kanamycin treatment. Polymyxin B treatment failed to affect scratching behavior. These results suggest that oral administration of kanamycin during infancy promoted the development of atopic dermatitis-like skin lesions in NC/Nga mice and was associated with a transient change in intestinal microbiota.
巻・号 74(2)
ページ 358-63
公開日 2010-1-1
DOI 10.1271/bbb.90709
PII JST.JSTAGE/bbb/90709
PMID 20139606
MeSH Administration, Oral Animals Anti-Bacterial Agents / administration & dosage Anti-Bacterial Agents / adverse effects* Dermatitis, Atopic / pathology* Female Immunoglobulin E / blood Mice Mice, Inbred Strains Pruritus / pathology Severity of Illness Index Skin / pathology*
IF 1.516
引用数 15
WOS 分野 FOOD SCIENCE & TECHNOLOGY CHEMISTRY, APPLIED BIOTECHNOLOGY & APPLIED MICROBIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY
リソース情報
一般微生物 JCM 1717