Reference - Detail
|Author||Takehara M, Hibino A, Saimura M, Hirohara H.|
|Title||High-yield production of short chain length poly(epsilon-L-lysine) consisting of 5-20 residues by Streptomyces aureofaciens, and its antimicrobial activity.|
Poly(epsilon-L-lysine) (epsilon-PL) is a naturally-occurring L-lysine homopolymer having antimicrobial activity. A newly-isolated strain of Streptomyces aureofaciens produced a short chain length epsilon-PL consisting of 5-20 residues at the highest production level of 4.5 g l(-1). This epsilon-PL had different spectra in terms of antimicrobial activity from the epsilon-PL that is now used as a food preservative. The high productivity was based on multiple metabolic pathways for L-lysine synthesis, and a great flux from L-lysine to epsilon-PL. The usefulness of this new epsilon-PL and its producing strain was discussed.
|MeSH||Amino Acids / analysis Anti-Bacterial Agents / biosynthesis* Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / pharmacology* Chromatography, High Pressure Liquid Metabolic Networks and Pathways / genetics Models, Biological Polylysine / biosynthesis* Polylysine / chemistry Polylysine / pharmacology* Streptomyces aureofaciens / metabolism*|
|WOS Category||BIOTECHNOLOGY & APPLIED MICROBIOLOGY|
|General Microbes||JCM 2788|