Reference - Detail
RRC ID | 7005 |
---|---|
Author | Takehara M, Hibino A, Saimura M, Hirohara H. |
Title | High-yield production of short chain length poly(epsilon-L-lysine) consisting of 5-20 residues by Streptomyces aureofaciens, and its antimicrobial activity. |
Journal | Biotechnol Lett |
Abstract |
Poly(epsilon-L-lysine) (epsilon-PL) is a naturally-occurring L-lysine homopolymer having antimicrobial activity. A newly-isolated strain of Streptomyces aureofaciens produced a short chain length epsilon-PL consisting of 5-20 residues at the highest production level of 4.5 g l(-1). This epsilon-PL had different spectra in terms of antimicrobial activity from the epsilon-PL that is now used as a food preservative. The high productivity was based on multiple metabolic pathways for L-lysine synthesis, and a great flux from L-lysine to epsilon-PL. The usefulness of this new epsilon-PL and its producing strain was discussed. |
Volume | 32(9) |
Pages | 1299-303 |
Published | 2010-9-1 |
DOI | 10.1007/s10529-010-0294-9 |
PMID | 20464451 |
MeSH | Amino Acids / analysis Anti-Bacterial Agents / biosynthesis* Anti-Bacterial Agents / chemistry Anti-Bacterial Agents / pharmacology* Chromatography, High Pressure Liquid Metabolic Networks and Pathways / genetics Models, Biological Polylysine / biosynthesis* Polylysine / chemistry Polylysine / pharmacology* Streptomyces aureofaciens / metabolism* |
IF | 1.977 |
Times Cited | 28 |
WOS Category | BIOTECHNOLOGY & APPLIED MICROBIOLOGY |
Resource | |
General Microbes | JCM 2788 |