Reference - Detail
| RRC ID | 70074 |
|---|---|
| Author | Kasai A, Jee E, Tamura Y, Kouzaki K, Kotani T, Nakazato K. |
| Title | Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice. |
| Journal | Am J Physiol Regul Integr Comp Physiol |
| Abstract |
Aldehyde dehydrogenase 2 (ALDH2) detoxifies acetaldehyde produced from ethanol. A missense single nucleotide polymorphism (SNP) rs671 in ALDH2 exhibits a dominant-negative form of the ALDH2 protein. Nearly 40% of people in East Asia carry an inactive ALDH2*2 mutation. Previous studies reported that ALDH2*2 is associated with increased risk of several diseases. In this study, we examined the effect of ALDH2 deficiency on age-related muscle atrophy and its underlying mechanisms. We found that ALDH2 deficiency promotes age-related loss of muscle fiber cross-sectional areas, especially in oxidative fibers. Furthermore, ALDH2 deficiency exacerbated age-related accumulation of 4-hydroxy-2-nonenal (4-HNE), a marker of oxidative stress in the gastrocnemius muscle. Similarly, mitochondrial reactive oxygen species (ROS) production increased in aged ALDH2-knockout mice, indicating that ALDH2 deficiency induced mitochondrial dysfunction. In summary, ALDH2 deficiency promotes age-related muscle loss, especially in oxidative fibers, which may be associated with an increased accumulation of oxidative stress via mitochondrial dysfunction. |
| Volume | 322(6) |
| Pages | R511-R525 |
| Published | 2022-6-1 |
| DOI | 10.1152/ajpregu.00304.2021 |
| PMID | 35318866 |
| MeSH | Aldehyde Dehydrogenase, Mitochondrial / genetics Aldehyde Dehydrogenase, Mitochondrial / metabolism Animals Humans Mice Mice, Inbred C57BL Muscle, Skeletal* / metabolism Muscular Atrophy* / genetics Muscular Atrophy* / metabolism Reactive Oxygen Species / metabolism |
| IF | 3.026 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC05808 |