論文 - 詳細
| RRC ID | 70316 |
|---|---|
| 著者 | Male I, Ozacar AT, Fagan RR, Loring MD, Shen MC, Pace VA, Devine CA, Lawson GE, Lutservitz A, Karlstrom RO. |
| タイトル | Hedgehog Signaling Regulates Neurogenesis in the Larval and Adult Zebrafish Hypothalamus. |
| ジャーナル | eNeuro |
| Abstract |
Neurogenesis is now known to play a role in adult hypothalamic function, yet the cell-cell mechanisms regulating this neurogenesis remain poorly understood. Here, we show that Hedgehog (Hh)/Gli signaling positively regulates hypothalamic neurogenesis in both larval and adult zebrafish and is necessary and sufficient for normal hypothalamic proliferation rates. Hh-responsive radial glia represent a relatively highly proliferative precursor population that gives rise to dopaminergic, serotonergic, and GABAergic neurons. In situ and transgenic reporter analyses revealed substantial heterogeneity in cell-cell signaling within the hypothalamic niche, with slow cycling Nestin-expressing cells residing among distinct and overlapping populations of Sonic Hh (Shh)-expressing, Hh-responsive, Notch-responsive, and Wnt-responsive radial glia. This work shows for the first time that Hh/Gli signaling is a key component of the complex cell-cell signaling environment that regulates hypothalamic neurogenesis throughout life. |
| 巻・号 | 7(6) |
| 公開日 | 2020-1-1 |
| DOI | 10.1523/ENEURO.0226-20.2020 |
| PII | ENEURO.0226-20.2020 |
| PMID | 33106384 |
| PMC | PMC7769882 |
| MeSH | Animals Hedgehog Proteins* / genetics Hedgehog Proteins* / metabolism Hypothalamus / metabolism Larva / metabolism Neurogenesis Signal Transduction Zebrafish* / metabolism |
| IF | 3.544 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(gad1b:GFP) |