RRC ID 70335
著者 Vandestadt C, Vanwalleghem GC, Khabooshan MA, Douek AM, Castillo HA, Li M, Schulze K, Don E, Stamatis SA, Ratnadiwakara M, Änkö ML, Scott EK, Kaslin J.
タイトル RNA-induced inflammation and migration of precursor neurons initiates neuronal circuit regeneration in zebrafish.
ジャーナル Dev Cell
Abstract Tissue regeneration and functional restoration after injury are considered as stem- and progenitor-cell-driven processes. In the central nervous system, stem cell-driven repair is slow and problematic because function needs to be restored rapidly for vital tasks. In highly regenerative vertebrates, such as zebrafish, functional recovery is rapid, suggesting a capability for fast cell production and functional integration. Surprisingly, we found that migration of dormant "precursor neurons" to the injury site pioneers functional circuit regeneration after spinal cord injury and controls the subsequent stem-cell-driven repair response. Thus, the precursor neurons make do before the stem cells make new. Furthermore, RNA released from the dying or damaged cells at the site of injury acts as a signal to attract precursor neurons for repair. Taken together, our data demonstrate an unanticipated role of neuronal migration and RNA as drivers of neural repair.
巻・号 56(16)
ページ 2364-2380.e8
公開日 2021-8-23
DOI 10.1016/j.devcel.2021.07.021
PII S1534-5807(21)00604-3
PMID 34428400
MeSH Animals Cell Movement* Nerve Regeneration* Neural Stem Cells / metabolism* Neural Stem Cells / physiology RNA / metabolism* Zebrafish
IF 10.092
リソース情報
ゼブラフィッシュ Tg(CM-isl1:GFP)rw0