論文 - 詳細
| RRC ID | 70402 |
|---|---|
| 著者 | Daitoku N, Miyamoto Y, Hiyoshi Y, Tokunaga R, Sakamoto Y, Sawayama H, Ishimoto T, Baba Y, Yoshida N, Baba H. |
| タイトル | Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer. |
| ジャーナル | Oncol Rep |
| Abstract |
Activin A is a member of the transforming growth factor‑β superfamily of cytokines and displays various pathophysiological activities, including regulation of muscle catabolism and atrophy. Activin A expression is upregulated in several human cancer types and in certain pathologies, its expression is associated with poor prognosis. In the present study, activin A expression was assessed in colorectal cancer (CRC) tissue specimens from 157 patients with primary CRC and the relationship between activin A levels and clinicopathological characteristics, including skeletal muscle mass, and prognosis, was determined. Furthermore, the effects of knockdown of endogenous or exposure to exogenous activin A on the malignant behavior of human CRC cell lines were investigated in vitro. The results indicated that activin A mRNA was significantly upregulated in CRC tumor tissues compared with normal intestinal epithelium. High activin A expression was significantly associated with shorter cancer‑specific survival (P=0.047) and overall survival (P=0.014). According to a multivariate analysis, tumor activin A levels were an independent prognostic factor for overall survival (P=0.001). However, activin A mRNA levels were not associated with the skeletal muscle index. The in vitro experiments demonstrated that exposure to exogenous activin A increased the proliferation, invasion and migration of CRC cell lines, whereas knockdown of endogenous activin A had the opposite effects. In conclusion, activin A is an autocrine and paracrine regulator of CRC cell proliferation and high tumor expression of activin A is associated with poor prognosis in patients with CRC. |
| 巻・号 | 47(6) |
| 公開日 | 2022-6-1 |
| DOI | 10.3892/or.2022.8318 |
| PII | 107 |
| PMID | 35445735 |
| PMC | PMC9073419 |
| MeSH | Activins Cell Line, Tumor Cell Movement / genetics Cell Proliferation / genetics Colorectal Neoplasms* / pathology Gene Expression Regulation, Neoplastic Humans Prognosis RNA, Messenger / genetics |
| IF | 3.417 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | LoVo(RCB1639) |