| RRC ID |
70402
|
| 著者 |
Daitoku N, Miyamoto Y, Hiyoshi Y, Tokunaga R, Sakamoto Y, Sawayama H, Ishimoto T, Baba Y, Yoshida N, Baba H.
|
| タイトル |
Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer.
|
| ジャーナル |
Oncol Rep
|
| Abstract |
Activin A is a member of the transforming growth factor‑β superfamily of cytokines and displays various pathophysiological activities, including regulation of muscle catabolism and atrophy. Activin A expression is upregulated in several human cancer types and in certain pathologies, its expression is associated with poor prognosis. In the present study, activin A expression was assessed in colorectal cancer (CRC) tissue specimens from 157 patients with primary CRC and the relationship between activin A levels and clinicopathological characteristics, including skeletal muscle mass, and prognosis, was determined. Furthermore, the effects of knockdown of endogenous or exposure to exogenous activin A on the malignant behavior of human CRC cell lines were investigated in vitro. The results indicated that activin A mRNA was significantly upregulated in CRC tumor tissues compared with normal intestinal epithelium. High activin A expression was significantly associated with shorter cancer‑specific survival (P=0.047) and overall survival (P=0.014). According to a multivariate analysis, tumor activin A levels were an independent prognostic factor for overall survival (P=0.001). However, activin A mRNA levels were not associated with the skeletal muscle index. The in vitro experiments demonstrated that exposure to exogenous activin A increased the proliferation, invasion and migration of CRC cell lines, whereas knockdown of endogenous activin A had the opposite effects. In conclusion, activin A is an autocrine and paracrine regulator of CRC cell proliferation and high tumor expression of activin A is associated with poor prognosis in patients with CRC.
|
| 巻・号 |
47(6)
|
| 公開日 |
2022-6-1
|
| DOI |
10.3892/or.2022.8318
|
| PII |
107
|
| PMID |
35445735
|
| PMC |
PMC9073419
|
| MeSH |
Activins
Cell Line, Tumor
Cell Movement / genetics
Cell Proliferation / genetics
Colorectal Neoplasms* / pathology
Gene Expression Regulation, Neoplastic
Humans
Prognosis
RNA, Messenger / genetics
|
| IF |
3.417
|
| リソース情報 |
| ヒト・動物細胞 |
LoVo(RCB1639) |
