論文 - 詳細
| RRC ID | 70576 |
|---|---|
| 著者 | Kaniganti T, Deogade A, Maduskar A, Mukherjee A, Guru A, Subhedar N, Ghose A. |
| タイトル | Sensitivity of olfactory sensory neurons to food cues is tuned to nutritional states by Neuropeptide Y signaling. |
| ジャーナル | J Neurochem |
| Abstract |
Modulation of sensory perception by homeostatic feedback from physiological states is central to innate purposive behaviors. Olfaction is an important predictive modality for feeding-related behaviors and its modulation has been associated with hunger-satiety states. However, the mechanisms mapping internal states to chemosensory processing in order to modify behavior are poorly understood. In the zebrafish olfactory epithelium, a subset of olfactory sensory neurons (OSNs) and the terminal nerve projections express neuropeptide Y (NPY). Using a combination of neuronal activity and behavioral evaluation, we find that NPY signaling in the peripheral olfactory system of zebrafish is correlated with its nutritional state and is both necessary and sufficient for the olfactory perception of food-related odorants. NPY activity dynamically modulates the microvillar OSN activation thresholds and acts cooperatively with amino acid signaling resulting in a switch-like increase in OSN sensitivity in starved animals. We suggest that cooperative activation of phospholipase C by convergent signaling from NPY and amino acid receptors is central to this heightened sensitivity. This study provides ethologically relevant, physiological evidence for NPY signaling in the modulation of OSN sensitivity to food-associated amino acid cues. We demonstrate sensory gating directly at the level of OSNs and identify a novel mechanistic framework for tuning olfactory sensitivity to prevailing energy states. Cover Image for this issue: https://doi.org/10.1111/jnc.15091. |
| 巻・号 | 159(6) |
| ページ | 1028-1044 |
| 公開日 | 2021-12-1 |
| DOI | 10.1111/jnc.15488 |
| PMID | 34359098 |
| MeSH | Animals Animals, Genetically Modified Cues* Eating / physiology* Female Humans Male Neuropeptide Y / analysis Neuropeptide Y / biosynthesis* Nutritional Status / physiology* Olfactory Mucosa / chemistry Olfactory Mucosa / metabolism* Olfactory Receptor Neurons / chemistry Olfactory Receptor Neurons / metabolism* Zebrafish |
| IF | 4.066 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(TRPC24.5k :gap-Venus)rw037 |