論文 - 詳細
| RRC ID | 70773 |
|---|---|
| 著者 | Kubrak O, Koyama T, Ahrentløv N, Jensen L, Malita A, Naseem MT, Lassen M, Nagy S, Texada MJ, Halberg KV, Rewitz K. |
| タイトル | The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress. |
| ジャーナル | Nat Commun |
| Abstract |
The intestine is a central regulator of metabolic homeostasis. Dietary inputs are absorbed through the gut, which senses their nutritional value and relays hormonal information to other organs to coordinate systemic energy balance. However, the gut-derived hormones affecting metabolic and behavioral responses are poorly defined. Here we show that the endocrine cells of the Drosophila gut sense nutrient stress through a mechanism that involves the TOR pathway and in response secrete the peptide hormone allatostatin C, a Drosophila somatostatin homolog. Gut-derived allatostatin C induces secretion of glucagon-like adipokinetic hormone to coordinate food intake and energy mobilization. Loss of gut Allatostatin C or its receptor in the adipokinetic-hormone-producing cells impairs lipid and sugar mobilization during fasting, leading to hypoglycemia. Our findings illustrate a nutrient-responsive endocrine mechanism that maintains energy homeostasis under nutrient-stress conditions, a function that is essential to health and whose failure can lead to metabolic disorders. |
| 巻・号 | 13(1) |
| ページ | 692 |
| 公開日 | 2022-2-4 |
| DOI | 10.1038/s41467-022-28268-x |
| PII | 10.1038/s41467-022-28268-x |
| PMID | 35121731 |
| PMC | PMC8816919 |
| MeSH | Animals Animals, Genetically Modified Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / genetics Drosophila melanogaster / metabolism Eating / genetics Eating / physiology* Energy Metabolism / genetics Energy Metabolism / physiology* Enteroendocrine Cells / metabolism Gastrointestinal Hormones / genetics Gastrointestinal Hormones / metabolism* Gene Knockout Techniques Homeostasis* Humans Hypoglycemia / genetics Hypoglycemia / metabolism Insect Hormones / genetics Insect Hormones / metabolism Nutrients / metabolism* Oligopeptides / genetics Oligopeptides / metabolism Pyrrolidonecarboxylic Acid / analogs & derivatives Pyrrolidonecarboxylic Acid / metabolism Receptors, G-Protein-Coupled / genetics Receptors, G-Protein-Coupled / metabolism Signal Transduction / genetics Somatostatin / genetics Somatostatin / metabolism* Survival Analysis |
| IF | 12.121 |
| リソース情報 | |
| ショウジョウバエ | DGRC#108492 |