RRC ID 70802
Author Yaksi E, Jamali A, Diaz Verdugo C, Jurisch-Yaksi N.
Title Past, present and future of zebrafish in epilepsy research.
Journal FEBS J
Abstract Animal models contribute greatly to our understanding of brain development and function as well as its dysfunction in neurological diseases. Epilepsy research is a very good example of how animal models can provide us with a mechanistic understanding of the genes, molecules, and pathophysiological processes involved in disease. Over the course of the last two decades, zebrafish came in as a new player in epilepsy research, with an expanding number of laboratories using this animal to understand epilepsy and to discover new strategies for preventing seizures. Yet, zebrafish as a model offers a lot more for epilepsy research. In this viewpoint, we aim to highlight some key contributions of zebrafish to epilepsy research, and we want to emphasize the great untapped potential of this animal model for expanding these contributions. We hope that our suggestions will trigger further discussions between clinicians and researchers with a common goal to understand and cure epilepsy.
Volume 288(24)
Pages 7243-7255
Published 2021-12-1
DOI 10.1111/febs.15694
PMID 33394550
MeSH Animals Disease Models, Animal Epilepsy / metabolism* Epilepsy / pathology Seizures / metabolism* Seizures / pathology Zebrafish
IF 4.392
Zebrafish Tg(vglut2a:loxP-DsRed-loxP-GFP) Tg(gad1b:GFP)