RRC ID 70877
Author Wee CL, Song E, Nikitchenko M, Herrera KJ, Wong S, Engert F, Kunes S.
Title Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish.
Journal Nat Commun
Abstract Animal brains have evolved to encode social stimuli and transform these representations into advantageous behavioral responses. The commonalities and differences of these representations across species are not well-understood. Here, we show that social isolation activates an oxytocinergic (OXT), nociceptive circuit in the larval zebrafish hypothalamus and that chemical cues released from conspecific animals are potent modulators of this circuit's activity. We delineate an olfactory to subpallial pathway that transmits chemical social cues to OXT circuitry, where they are transformed into diverse outputs simultaneously regulating avoidance and feeding behaviors. Our data allow us to propose a model through which social stimuli are integrated within a fundamental neural circuit to mediate diverse adaptive behaviours.
Volume 13(1)
Pages 2573
Published 2022-5-11
DOI 10.1038/s41467-022-29765-9
PII 10.1038/s41467-022-29765-9
PMID 35545618
PMC PMC9095721
MeSH Animals Appetite Avoidance Learning* Behavior, Animal Larva / physiology Social Behavior Social Isolation Zebrafish* / metabolism
IF 12.121
Zebrafish Tg(gad1b:|R|-GFP) UAS:GCaMP6s