論文 - 詳細
| RRC ID | 71285 |
|---|---|
| 著者 | Tsukuda N, Yahagi K, Hara T, Watanabe Y, Matsumoto H, Mori H, Higashi K, Tsuji H, Matsumoto S, Kurokawa K, Matsuki T. |
| タイトル | Key bacterial taxa and metabolic pathways affecting gut short-chain fatty acid profiles in early life. |
| ジャーナル | ISME J |
| Abstract |
Infant gut microbiota development affects the host physiology throughout life, and short-chain fatty acids (SCFAs) are promising key metabolites mediating microbiota-host relationships. Here, we investigated dense longitudinally collected faecal samples from 12 subjects during the first 2 years (n = 1048) to identify early life gut SCFA patterns and their relationships with the microbiota. Our results revealed three distinct phases of progression in the SCFA profiles: early phase characterised by low acetate and high succinate, middle-phase characterised by high lactate and formate and late-phase characterised by high propionate and butyrate. Assessment of the SCFA-microbiota relationships revealed that faecal butyrate is associated with increased Clostridiales and breastfeeding cessation, and that diverse and personalised assemblage of Clostridiales species possessing the acetyl-CoA pathway play major roles in gut butyrate production. We also found an association between gut formate and some infant-type bifidobacterial species, and that human milk oligosaccharides (HMO)-derived fucose is the substrate for formate production during breastfeeding. We identified genes upregulated in fucose and fucosylated HMO utilisation in infant-type bifidobacteria. Notably, bifidobacteria showed interspecific and intraspecific variation in the gene repertoires, and cross-feeding of fucose contributed to gut formate production. This study provides an insight into early life SCFA-microbiota relationships, which is an important step for developing strategies for modulating lifelong health. |
| 巻・号 | 15(9) |
| ページ | 2574-2590 |
| 公開日 | 2021-9-1 |
| DOI | 10.1038/s41396-021-00937-7 |
| PII | 10.1038/s41396-021-00937-7 |
| PMID | 33723382 |
| PMC | PMC8397723 |
| MeSH | Clostridiales Fatty Acids, Volatile* Female Gastrointestinal Microbiome* Humans Infant Metabolic Networks and Pathways Milk, Human |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 38 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM1192 JCM1222 JCM1217 JCM1194 JCM15439 |