| RRC ID |
71290
|
| Author |
Igarashi M, Sawa R, Umekita M, Hatano M, Arisaka R, Hayashi C, Ishizaki Y, Suzuki M, Kato C.
|
| Title |
Sealutomicins, new enediyne antibiotics from the deep-sea actinomycete Nonomuraea sp. MM565M-173N2.
|
| Journal |
J Antibiot (Tokyo)
|
| Abstract |
A Nonomuraea sp. strain MM565M-173N2 was isolated from deep-sea sediment off the Sanriku coast, and new antibiotics were evaluated against carbapenem-resistant Enterobacteriaceae (CRE), which is a problematic group of bacteria because of their antimicrobial resistance. From 220 l of fermented broth from strain MM565M-173N2, we isolated four new antibiotics by gel filtration and HPLC, designated as sealutomicins A (1.8 mg), B (1.5 mg), C (0.8 mg), and D (0.8 mg). Their structures were determined from MS, NMR, and CD spectra. Sealutomicin A was found to be a new enediyne antibiotic, while sealutomicins B-D were aromatized products from sealutomicin A. Sealutomicin A showed strong antibacterial activity (MIC 0.05-0.2 μg ml-1) against CRE.
|
| Volume |
74(5)
|
| Pages |
291-299
|
| Published |
2021-5-1
|
| DOI |
10.1038/s41429-020-00402-1
|
| PII |
10.1038/s41429-020-00402-1
|
| PMID |
33531630
|
| MeSH |
Actinobacteria / metabolism*
Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / metabolism*
Fermentation
Geologic Sediments / microbiology
Molecular Structure
|
| Resource |
| General Microbes |
JCM5803
JCM5804 |
