論文 - 詳細
| RRC ID | 71315 |
|---|---|
| 著者 | Katsuki R, Shiraishi T, Sakata S, Hirota T, Nakamura Y, Yokota SI. |
| タイトル | Inhibitory Effect of the Glycerophosphate Moiety of Lipoteichoic Acid from Lactic Acid Bacteria on Dexamethasone-Induced Atrogin-1 Expression in C2C12 Myotubes. |
| ジャーナル | J Nutr Sci Vitaminol (Tokyo) |
| Abstract |
Atrogin-1, which is an important regulator of ubiquitin-mediated protein degradation in skeletal muscle, is a major marker of muscle loss and disuse muscle atrophy. To investigate which components of lactic acid bacteria (LAB) suppress dexamethasone (DEX)-induced atrogin-1 expression, mouse skeletal muscle C2C12 myotubes were treated with DEX in the presence or absence of components of LAB. Heat-killed cells and lipoteichoic acid (LTA) derived from five LAB strains significantly suppressed DEX-induced atrogin-1 expression. The glycerophosphate (GroP) fraction prepared from chemically-degraded LTA and sn-glycerol-1-phosphate suppressed DEX-induced atrogin-1 expression, whereas the glycolipid anchor fraction of LTA did not. Heat-killed cells obtained by culturing under low-Mn2+ conditions, which generated fewer poly-GroP polymers in LTA, displayed significantly lower inhibitory activity compared to heat-killed cells grown under normal conditions. These results suggested that LTA of LAB contributed to suppressing atrogin-1 expression and that the GroP moiety of LTA was responsible for its inhibitory activity. |
| 巻・号 | 67(5) |
| ページ | 351-357 |
| 公開日 | 2021-1-1 |
| DOI | 10.3177/jnsv.67.351 |
| PMID | 34719621 |
| MeSH | Animals Dexamethasone / pharmacology Glycerophosphates Lactobacillales* Lipopolysaccharides Mice Muscle Fibers, Skeletal Muscle Proteins Muscle, Skeletal / pathology Muscular Atrophy* / pathology SKP Cullin F-Box Protein Ligases Teichoic Acids Ubiquitin-Protein Ligases |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 一般微生物 | JCM1131 JCM1136 JCM1149 JCM1558 JCM1559 |