| RRC ID |
71463
|
| 著者 |
Endo D, Kobayashi R, Bartolo R, Averbeck BB, Sugase-Miyamoto Y, Hayashi K, Kawano K, Richmond BJ, Shinomoto S.
|
| タイトル |
A convolutional neural network for estimating synaptic connectivity from spike trains.
|
| ジャーナル |
Sci Rep
|
| Abstract |
The recent increase in reliable, simultaneous high channel count extracellular recordings is exciting for physiologists and theoreticians because it offers the possibility of reconstructing the underlying neuronal circuits. We recently presented a method of inferring this circuit connectivity from neuronal spike trains by applying the generalized linear model to cross-correlograms. Although the algorithm can do a good job of circuit reconstruction, the parameters need to be carefully tuned for each individual dataset. Here we present another method using a Convolutional Neural Network for Estimating synaptic Connectivity from spike trains. After adaptation to huge amounts of simulated data, this method robustly captures the specific feature of monosynaptic impact in a noisy cross-correlogram. There are no user-adjustable parameters. With this new method, we have constructed diagrams of neuronal circuits recorded in several cortical areas of monkeys.
|
| 巻・号 |
11(1)
|
| ページ |
12087
|
| 公開日 |
2021-6-8
|
| DOI |
10.1038/s41598-021-91244-w
|
| PII |
10.1038/s41598-021-91244-w
|
| PMID |
34103546
|
| PMC |
PMC8187444
|
| MeSH |
Action Potentials / physiology*
Algorithms
Animals
Computer Simulation
Linear Models
Macaca fuscata
Male
Models, Neurological*
Models, Theoretical
Neural Networks, Computer*
Neural Pathways / physiology
Neurons / physiology
Neurosciences
Signal Processing, Computer-Assisted
Synapses / metabolism
Temporal Lobe / physiology
Visual Cortex / pathology
Visual Cortex / physiology
|
| IF |
3.998
|
| リソース情報 |
| ニホンザル |
|
