RRC ID 71465
Author Hori Y, Nagai Y, Mimura K, Suhara T, Higuchi M, Bouret S, Minamimoto T.
Title D1- and D2-like receptors differentially mediate the effects of dopaminergic transmission on cost-benefit evaluation and motivation in monkeys.
Journal PLoS Biol
Abstract It has been widely accepted that dopamine (DA) plays a major role in motivation, yet the specific contribution of DA signaling at D1-like receptor (D1R) and D2-like receptor (D2R) to cost-benefit trade-off remains unclear. Here, by combining pharmacological manipulation of DA receptors (DARs) and positron emission tomography (PET) imaging, we assessed the relationship between the degree of D1R/D2R blockade and changes in benefit- and cost-based motivation for goal-directed behavior of macaque monkeys. We found that the degree of blockade of either D1R or D2R was associated with a reduction of the positive impact of reward amount and increasing delay discounting. Workload discounting was selectively increased by D2R antagonism. In addition, blocking both D1R and D2R had a synergistic effect on delay discounting but an antagonist effect on workload discounting. These results provide fundamental insight into the distinct mechanisms of DA action in the regulation of the benefit- and cost-based motivation, which have important implications for motivational alterations in both neurological and psychiatric disorders.
Volume 19(7)
Pages e3001055
Published 2021-7-1
DOI 10.1371/journal.pbio.3001055
PMID 34197448
PMC PMC8248602
MeSH Animals Cost-Benefit Analysis* Delay Discounting Dopamine / metabolism* Dopamine Antagonists / pharmacology Macaca fuscata Macaca mulatta / physiology* Male Motivation* Positron-Emission Tomography Receptors, Dopamine D1 / drug effects Receptors, Dopamine D1 / physiology* Receptors, Dopamine D2 / drug effects Receptors, Dopamine D2 / physiology* Workload
IF 7.076
Japanese macaques