論文 - 詳細
| RRC ID | 71465 |
|---|---|
| 著者 | Hori Y, Nagai Y, Mimura K, Suhara T, Higuchi M, Bouret S, Minamimoto T. |
| タイトル | D1- and D2-like receptors differentially mediate the effects of dopaminergic transmission on cost-benefit evaluation and motivation in monkeys. |
| ジャーナル | PLoS Biol |
| Abstract |
It has been widely accepted that dopamine (DA) plays a major role in motivation, yet the specific contribution of DA signaling at D1-like receptor (D1R) and D2-like receptor (D2R) to cost-benefit trade-off remains unclear. Here, by combining pharmacological manipulation of DA receptors (DARs) and positron emission tomography (PET) imaging, we assessed the relationship between the degree of D1R/D2R blockade and changes in benefit- and cost-based motivation for goal-directed behavior of macaque monkeys. We found that the degree of blockade of either D1R or D2R was associated with a reduction of the positive impact of reward amount and increasing delay discounting. Workload discounting was selectively increased by D2R antagonism. In addition, blocking both D1R and D2R had a synergistic effect on delay discounting but an antagonist effect on workload discounting. These results provide fundamental insight into the distinct mechanisms of DA action in the regulation of the benefit- and cost-based motivation, which have important implications for motivational alterations in both neurological and psychiatric disorders. |
| 巻・号 | 19(7) |
| ページ | e3001055 |
| 公開日 | 2021-7-1 |
| DOI | 10.1371/journal.pbio.3001055 |
| PII | PBIOLOGY-D-20-03178 |
| PMID | 34197448 |
| PMC | PMC8248602 |
| MeSH | Animals Cost-Benefit Analysis* Delay Discounting Dopamine / metabolism* Dopamine Antagonists / pharmacology Macaca fuscata Macaca mulatta / physiology* Male Motivation* Positron-Emission Tomography Receptors, Dopamine D1 / drug effects Receptors, Dopamine D1 / physiology* Receptors, Dopamine D2 / drug effects Receptors, Dopamine D2 / physiology* Workload |
| IF | 7.076 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 33 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ニホンザル | |