| RRC ID |
71465
|
| 著者 |
Hori Y, Nagai Y, Mimura K, Suhara T, Higuchi M, Bouret S, Minamimoto T.
|
| タイトル |
D1- and D2-like receptors differentially mediate the effects of dopaminergic transmission on cost-benefit evaluation and motivation in monkeys.
|
| ジャーナル |
PLoS Biol
|
| Abstract |
It has been widely accepted that dopamine (DA) plays a major role in motivation, yet the specific contribution of DA signaling at D1-like receptor (D1R) and D2-like receptor (D2R) to cost-benefit trade-off remains unclear. Here, by combining pharmacological manipulation of DA receptors (DARs) and positron emission tomography (PET) imaging, we assessed the relationship between the degree of D1R/D2R blockade and changes in benefit- and cost-based motivation for goal-directed behavior of macaque monkeys. We found that the degree of blockade of either D1R or D2R was associated with a reduction of the positive impact of reward amount and increasing delay discounting. Workload discounting was selectively increased by D2R antagonism. In addition, blocking both D1R and D2R had a synergistic effect on delay discounting but an antagonist effect on workload discounting. These results provide fundamental insight into the distinct mechanisms of DA action in the regulation of the benefit- and cost-based motivation, which have important implications for motivational alterations in both neurological and psychiatric disorders.
|
| 巻・号 |
19(7)
|
| ページ |
e3001055
|
| 公開日 |
2021-7-1
|
| DOI |
10.1371/journal.pbio.3001055
|
| PII |
PBIOLOGY-D-20-03178
|
| PMID |
34197448
|
| PMC |
PMC8248602
|
| MeSH |
Animals
Cost-Benefit Analysis*
Delay Discounting
Dopamine / metabolism*
Dopamine Antagonists / pharmacology
Macaca fuscata
Macaca mulatta / physiology*
Male
Motivation*
Positron-Emission Tomography
Receptors, Dopamine D1 / drug effects
Receptors, Dopamine D1 / physiology*
Receptors, Dopamine D2 / drug effects
Receptors, Dopamine D2 / physiology*
Workload
|
| IF |
7.076
|
| リソース情報 |
| ニホンザル |
|
