Reference - Detail
| RRC ID | 71649 |
|---|---|
| Author | Hirota A, Taki S, Kawaii S, Yano M, Abe N. |
| Title | 1,1-Diphenyl-2-picrylhydrazyl radical-scavenging compounds from soybean miso and antiproliferative activity of isoflavones from soybean miso toward the cancer cell lines. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
Guided by their DPPH radical-scavenging activity, nine compounds were isolated from soybean miso. Of these, 8-hydroxydaidzein, 8-hydroxygenistein and syringic acid had as high DPPH radical-scavenging activity as that of alpha-tocopherol. The antiproliferative activity of four of the isolated isoflavones toward three cancer cell lines was examined. 8-Hydroxygenistein showed the highest activity (IC50=5.2 microM) toward human promyelocytic leukemia cells (HL-60). |
| Volume | 64(5) |
| Pages | 1038-40 |
| Published | 2000-5-1 |
| DOI | 10.1271/bbb.64.1038 |
| PMID | 10879475 |
| MeSH | Animals Antineoplastic Agents, Phytogenic / pharmacology* Bepridil / analogs & derivatives* Biphenyl Compounds Cell Division / drug effects* Coumaric Acids / metabolism Coumaric Acids / pharmacology Drug Screening Assays, Antitumor Fermentation Free Radical Scavengers / isolation & purification* Free Radical Scavengers / metabolism Free Radical Scavengers / pharmacology* Free Radicals Genistein / metabolism Genistein / pharmacology Humans Isoflavones / chemistry Isoflavones / pharmacology* Mice Picrates* Soybeans / chemistry* Soybeans / metabolism Tumor Cells, Cultured |
| IF | 1.516 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Blogs |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | HL60(RCB0041) A549(RCB0098) B16 melanoma 4A5(RCB0557) |