論文 - 詳細
| RRC ID | 71730 |
|---|---|
| 著者 | Hino SI, Inenaga K, Miyazaki T, Tanaka-Mizota C. |
| タイトル | Suppression of HCT116 Human Colon Cancer Cell Motility by Polymethoxyflavones is Associated with Inhibition of Wnt/β-Catenin Signaling. |
| ジャーナル | Nutr Cancer |
| Abstract |
Aberrant regulation of the Wnt/β-catenin signaling pathway is one of the major causes of colorectal cancer (CRC). In this study, we examined the effect of polymethoxyflavones present in citrus peels on Wnt/β-catenin signaling in the HCT116 CRC cell line. We found that 5,7,3',4'-tetra-methoxyflavone (TMF) and 7,8,3',4'-TMF inhibited the expression of target genes of Wnt/β-catenin signaling and the transcriptional activities of β-catenin/Tcf and suppressed the motility of HCT116 cells. Because the binding of β-catenin to Tcf-4 was disrupted by 5,7,3',4'-TMF and 7,8,3',4'- TMF, we suggest that they are inhibitors of the Wnt/β-catenin signaling and may have potential applications in CRC prevention. |
| 巻・号 | 74(10) |
| ページ | 3662-3669 |
| 公開日 | 2022-1-1 |
| DOI | 10.1080/01635581.2022.2084122 |
| PMID | 35658755 |
| MeSH | Cell Line, Tumor Cell Movement Cell Proliferation Colonic Neoplasms* / metabolism Colorectal Neoplasms* / metabolism Gene Expression Regulation, Neoplastic HCT116 Cells Humans Wnt Signaling Pathway beta Catenin / metabolism |
| IF | 2.363 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HCT116(RCB2979) |