論文 - 詳細
| RRC ID | 71859 |
|---|---|
| 著者 | Banshoya K, Fujita C, Hokimoto Y, Ohnishi M, Inoue A, Tanaka T, Kaneo Y. |
| タイトル | Amphotericin B nanohydrogel ocular formulation using alkyl glyceryl hyaluronic acid: Formulation, characterization, and in vitro evaluation. |
| ジャーナル | Int J Pharm |
| Abstract |
The present study focused on the development of an amphotericin B (AmB) nanoformulation for ophthalmic applications. Accordingly, AmB nanohydrogels (AHA/AmB) using alkyl glyceryl hyaluronic acid (Hyalorepair®, AHA), a hydrophobized hyaluronic acid, were prepared by employing the dialysis method, followed by assessments of physical properties, drug efficacy, and toxicity. In the AHA/AmB formulation, AmB existed in a self-aggregated and amorphous state in the hydrophobic environment of the AHA moiety. AHA/AmB was shown in vitro to interact with mucin, which is known to be expressed in the corneal epithelium and was expected to improve its corneal retention. Compared with the conventional AmB formulation, amphotericin B sodium deoxycholate, AHA/AmB had the same in vitro antifungal activity but significantly lower in vitro toxicity. These findings indicate that nanohydrogels prepared with AHA possess high fungal selectivity and serve as a promising system for ophthalmic AmB delivery. |
| 巻・号 | 610 |
| ページ | 121061 |
| 公開日 | 2021-12-15 |
| DOI | 10.1016/j.ijpharm.2021.121061 |
| PII | S0378-5173(21)00867-X |
| PMID | 34481008 |
| MeSH | Amphotericin B* / toxicity Antifungal Agents / toxicity Fungi Hyaluronic Acid* Hydrophobic and Hydrophilic Interactions |
| IF | 4.845 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HCE-T(RCB2280) |