Reference - Detail
| RRC ID | 71909 |
|---|---|
| Author | Yamada Y, Zhong Y, Miki S, Taura A, Rabbitts TH. |
| Title | The transcription factor complex LMO2/TAL1 regulates branching and endothelial cell migration in sprouting angiogenesis. |
| Journal | Sci Rep |
| Abstract |
The transcription factor complex, consisting of LMO2, TAL1 or LYL1, and GATA2, plays an important role in capillary sprouting by regulating VEGFR2, DLL4, and angiopoietin 2 in tip cells. Overexpression of the basic helix-loop-helix transcription factor LYL1 in transgenic mice results in shortened tails. This phenotype is associated with vessel hyperbranching and a relative paucity of straight vessels due to DLL4 downregulation in tip cells by forming aberrant complex consisting of LMO2 and LYL1. Knockdown of LMO2 or TAL1 inhibits capillary sprouting in spheroid-based angiogenesis assays, which is associated with decreased angiopoietin 2 secretion. In the same assay using mixed TAL1- and LYL1-expressing endothelial cells, TAL1 was found to be primarily located in tip cells, while LYL1-expressing cells tended to occupy the stalk position in sprouts by upregulating VEGFR1 than TAL1. Thus, the interaction between LMO2 and TAL1 in tip cells plays a key role in angiogenic switch of sprouting angiogenesis. |
| Volume | 12(1) |
| Pages | 7226 |
| Published | 2022-5-4 |
| DOI | 10.1038/s41598-022-11297-3 |
| PII | 10.1038/s41598-022-11297-3 |
| PMID | 35508511 |
| PMC | PMC9068620 |
| MeSH | Adaptor Proteins, Signal Transducing / metabolism* Angiopoietin-2* Animals Basic Helix-Loop-Helix Transcription Factors / genetics Endothelial Cells LIM Domain Proteins / genetics LIM Domain Proteins / metabolism* Mice Neoplasm Proteins / genetics Neovascularization, Physiologic / genetics T-Cell Acute Lymphocytic Leukemia Protein 1 / genetics |
| IF | 3.998 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 3.0 |
| Resource | |
| Mice | RBRC01839 |
| DNA material | BOSTAL1 (RDB19985) BOSmLYL1 (RDB19986) BOS beta gal (RDB19987) |