| RRC ID |
72021
|
| Author |
Mang D, Roy SR, Zhang Q, Hu X, Zhang Y.
|
| Title |
Heparan Sulfate-Instructed Self-Assembly Selectively Inhibits Cancer Cell Migration.
|
| Journal |
ACS Appl Mater Interfaces
|
| Abstract |
Heparan sulfate (HS) has important emerging roles in oncogenesis, which represents potential therapeutic strategies for human cancers. However, due to the complexity of the HS signaling network, HS-targeted synthetic cancer therapeutics has never been successfully devised. To conquer the challenge, we developed HS-instructed self-assembling peptides by decorating the "Cardin-Weintraub" sequence with aromatic amino acids. The HS-binding interactions induce localized accumulation of synthetic peptides triggering molecular self-assembly in the vicinity of highly expressed Heparan sulfate proteoglycans (HSPGs) on the cancer cell membrane. The nanostructures hinder the binding of HSPG with metastasis promoting protein-heparin-binding EGF-like growth factor (HBEGF) inhibiting the activation of focal adhesion kinase (FAK) and extracellular signal-regulated kinase (ERK). Our study proved that HS-instructed self-assembly is a promising synthetic therapeutic strategy for targeted cancer migration inhibition.
|
| Volume |
13(15)
|
| Pages |
17236-17242
|
| Published |
2021-4-21
|
| DOI |
10.1021/acsami.1c00934
|
| PMID |
33830729
|
| MeSH |
Cell Line, Tumor
Cell Movement / drug effects*
Extracellular Signal-Regulated MAP Kinases / metabolism
Heparitin Sulfate / chemistry*
Heparitin Sulfate / pharmacology*
Humans
Nanostructures / chemistry
Neoplasm Metastasis
|
| IF |
8.758
|
| Resource |
| Human and Animal Cells |
PANC-1(RCB2095) |
