| RRC ID |
72177
|
| 著者 |
Barberio AE, Smith SG, Correa S, Nguyen C, Nhan B, Melo M, Tokatlian T, Suh H, Irvine DJ, Hammond PT.
|
| タイトル |
Cancer Cell Coating Nanoparticles for Optimal Tumor-Specific Cytokine Delivery.
|
| ジャーナル |
ACS Nano
|
| Abstract |
Although cytokine therapy is an attractive strategy to build a more robust immune response in tumors, cytokines have faced clinical failures due to toxicity. In particular, interleukin-12 has shown great clinical promise but was limited in translation because of systemic toxicity. In this study, we demonstrate an enhanced ability to reduce toxicity without affecting the efficacy of IL-12 therapy. We engineer the material properties of a NP to meet the enhanced demands for optimal cytokine delivery by using the layer-by-layer (LbL) approach. Importantly, using LbL, we demonstrate cell-level trafficking of NPs to preferentially localize to the cell's outer surface and act as a drug depot, which is required for optimal payload activity on neighboring cytokine membrane receptors. LbL-NPs showed efficacy against a tumor challenge in both colorectal and ovarian tumors at doses that were not tolerated when administered carrier-free.
|
| 巻・号 |
14(9)
|
| ページ |
11238-11253
|
| 公開日 |
2020-9-22
|
| DOI |
10.1021/acsnano.0c03109
|
| PMID |
32692155
|
| PMC |
PMC7530125
|
| MeSH |
Cytokines
Drug Delivery Systems
Humans
Nanoparticles*
Neoplasms* / drug therapy
|
| IF |
14.588
|
| リソース情報 |
| ヒト・動物細胞 |
OV2944-HM-1(RCB1483) |
