RRC ID 72301
Author Van Dien M, Takahashi K, Mu MM, Koide N, Sugiyama T, Mori I, Yoshida T, Yokochi T.
Title Protective effect of wogonin on endotoxin-induced lethal shock in D-galactosamine-sensitized mice.
Journal Microbiol Immunol
Abstract The effects of wogonin, a major flavonoid from Scutellaria baicalensis Georgi, on lipopolysaccharide (LPS)-induced lethal shock in mice was investigated. Wogonin pretreatment prevented the lethal shock in mice injected with D-galactosamine (D-GalN) and LPS, but not in mice injected with a high dose of LPS. Wogonin definitely inhibited the hepatic injury in mice injected with D-GalN, and LPS and reduced the level of circulating tumor necrosis factor (TNF)-alpha. The reduction was more marked in mice injected with D-GalN and LPS compared with that in mice injected with a high dose of LPS. Wogonin pretreatment did not inhibit the lipid peroxidation in mice receiving either D-GalN and LPS or a high dose of LPS. Wogonin inhibited the in vitro production of TNF-alpha and nitric oxide in LPS-stimulated RAW 264.7 cells. The mechanism of the protective effect of wogonin on the lethal shock in mice injected with D-GalN and LPS is discussed.
Volume 45(11)
Pages 751-6
Published 2001-1-1
DOI 10.1111/j.1348-0421.2001.tb01311.x
PMID 11791668
MeSH Animals Antioxidants / pharmacology Antioxidants / therapeutic use* Cells, Cultured Female Flavanones* Flavonoids / pharmacology Flavonoids / therapeutic use* Galactosamine Lipid Peroxides / metabolism Lipopolysaccharides Liver / drug effects Liver / pathology Macrophages / drug effects Macrophages / metabolism Mice Mice, Inbred BALB C Nitric Oxide / metabolism Shock, Septic / chemically induced Shock, Septic / mortality Shock, Septic / prevention & control* Tumor Necrosis Factor-alpha / metabolism
IF 1.566
Human and Animal Cells RAW 264(RCB0535)