RRC ID |
72301
|
著者 |
Van Dien M, Takahashi K, Mu MM, Koide N, Sugiyama T, Mori I, Yoshida T, Yokochi T.
|
タイトル |
Protective effect of wogonin on endotoxin-induced lethal shock in D-galactosamine-sensitized mice.
|
ジャーナル |
Microbiol Immunol
|
Abstract |
The effects of wogonin, a major flavonoid from Scutellaria baicalensis Georgi, on lipopolysaccharide (LPS)-induced lethal shock in mice was investigated. Wogonin pretreatment prevented the lethal shock in mice injected with D-galactosamine (D-GalN) and LPS, but not in mice injected with a high dose of LPS. Wogonin definitely inhibited the hepatic injury in mice injected with D-GalN, and LPS and reduced the level of circulating tumor necrosis factor (TNF)-alpha. The reduction was more marked in mice injected with D-GalN and LPS compared with that in mice injected with a high dose of LPS. Wogonin pretreatment did not inhibit the lipid peroxidation in mice receiving either D-GalN and LPS or a high dose of LPS. Wogonin inhibited the in vitro production of TNF-alpha and nitric oxide in LPS-stimulated RAW 264.7 cells. The mechanism of the protective effect of wogonin on the lethal shock in mice injected with D-GalN and LPS is discussed.
|
巻・号 |
45(11)
|
ページ |
751-6
|
公開日 |
2001-1-1
|
DOI |
10.1111/j.1348-0421.2001.tb01311.x
|
PMID |
11791668
|
MeSH |
Animals
Antioxidants / pharmacology
Antioxidants / therapeutic use*
Cells, Cultured
Female
Flavanones*
Flavonoids / pharmacology
Flavonoids / therapeutic use*
Galactosamine
Lipid Peroxides / metabolism
Lipopolysaccharides
Liver / drug effects
Liver / pathology
Macrophages / drug effects
Macrophages / metabolism
Mice
Mice, Inbred BALB C
Nitric Oxide / metabolism
Shock, Septic / chemically induced
Shock, Septic / mortality
Shock, Septic / prevention & control*
Tumor Necrosis Factor-alpha / metabolism
|
IF |
1.566
|
リソース情報 |
ヒト・動物細胞 |
RAW 264(RCB0535) |