| RRC ID |
72383
|
| Author |
Hamada T, Ui-Tei K, Imaki J, Miyata Y.
|
| Title |
Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein.
|
| Journal |
Biochem Biophys Res Commun
|
| Abstract |
Spinal cord-derived growth factor (SCDGF)/platelet-derived growth factor (PDGF)-C/fallotein has a unique two-domain structure, as it contains two regions homologousto CUB and PDGF/vascular endothelial growth factor (VEGF) domains. In this study, we isolateda novel gene homologous to SCDGF/PDGF-C/fallotein, and named SCDGF-B. The culture supernatant of CHO-K1 cells stably transfected with SCDGF-B showed mitogenic activity as SCDGF/PDGF-C/fallotein did. Although SCDGF-B and SCDGF/PDGF-C/fallotein might be the members of the PDGF/VEGF superfamily of growth factors, they were categorized into a new subfamily in addition to PDGF and VEGF subfamilies.
|
| Volume |
280(3)
|
| Pages |
733-7
|
| Published |
2001-1-26
|
| DOI |
10.1006/bbrc.2000.4187
|
| PII |
S0006-291X(00)94187-1
|
| PMID |
11162582
|
| MeSH |
Amino Acid Sequence
Animals
Base Sequence
CHO Cells
Cloning, Molecular
Cricetinae
DNA Primers / genetics
Humans
Lymphokines / chemistry
Lymphokines / genetics*
Lymphokines / pharmacology
Mitogens / pharmacology
Molecular Sequence Data
Phylogeny
Platelet-Derived Growth Factor / chemistry
Platelet-Derived Growth Factor / genetics*
Platelet-Derived Growth Factor / pharmacology
Protein Structure, Tertiary
Rats
Recombinant Proteins / chemistry
Recombinant Proteins / genetics
Recombinant Proteins / pharmacology
Sequence Homology, Amino Acid
Transfection
|
| IF |
2.985
|
| Resource |
| Human and Animal Cells |
CHO-K1(RCB0285)
10T1/2 (RCB0247) |
