RRC ID 72383
Author Hamada T, Ui-Tei K, Imaki J, Miyata Y.
Title Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein.
Journal Biochem Biophys Res Commun
Abstract Spinal cord-derived growth factor (SCDGF)/platelet-derived growth factor (PDGF)-C/fallotein has a unique two-domain structure, as it contains two regions homologousto CUB and PDGF/vascular endothelial growth factor (VEGF) domains. In this study, we isolateda novel gene homologous to SCDGF/PDGF-C/fallotein, and named SCDGF-B. The culture supernatant of CHO-K1 cells stably transfected with SCDGF-B showed mitogenic activity as SCDGF/PDGF-C/fallotein did. Although SCDGF-B and SCDGF/PDGF-C/fallotein might be the members of the PDGF/VEGF superfamily of growth factors, they were categorized into a new subfamily in addition to PDGF and VEGF subfamilies.
Volume 280(3)
Pages 733-7
Published 2001-1-26
DOI 10.1006/bbrc.2000.4187
PII S0006-291X(00)94187-1
PMID 11162582
MeSH Amino Acid Sequence Animals Base Sequence CHO Cells Cloning, Molecular Cricetinae DNA Primers / genetics Humans Lymphokines / chemistry Lymphokines / genetics* Lymphokines / pharmacology Mitogens / pharmacology Molecular Sequence Data Phylogeny Platelet-Derived Growth Factor / chemistry Platelet-Derived Growth Factor / genetics* Platelet-Derived Growth Factor / pharmacology Protein Structure, Tertiary Rats Recombinant Proteins / chemistry Recombinant Proteins / genetics Recombinant Proteins / pharmacology Sequence Homology, Amino Acid Transfection
IF 2.985
Human and Animal Cells CHO-K1(RCB0285) 10T1/2 (RCB0247)