| RRC ID |
72444
|
| 著者 |
Tsunemi S, Iwasaki T, Kitano S, Imado T, Miyazawa K, Sano H.
|
| タイトル |
Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model.
|
| ジャーナル |
Clin Immunol
|
| Abstract |
We investigated the effects and mechanisms by which FTY720 (FTY) inhibits arthritis development in the SKG mouse rheumatoid arthritis (RA) model. FTY (1mg/kg/day) administration suppressed the progression of laminarin-induced arthritis in SKG mice. FTY treatment decreased IL-6 and TNF-alpha expression in synovial fibroblast cells and the number of inflammatory cells overall. Bone destruction was also suppressed by treatment with FTY. The numbers of CD4(+) and CD8(+) T cells were significantly increased in the thymus and decreased in the spleen in FTY-treated SKG mice. FTY enhanced IL-4 production by CD4(+) T cells stimulated by allogeneic spleen cells and inhibited prostaglandin E(2) (PGE(2)) production by a TNF-alpha-stimulated synovial fibroblast cell line. These results indicate that FTY can inhibit arthritis in SKG mice via sequestration of autoimmune CD4(+) T cells in the thymus, enhancement of Th2 immune responses, and inhibition of PGE(2) production by synovial cells.
|
| 巻・号 |
136(2)
|
| ページ |
197-204
|
| 公開日 |
2010-8-1
|
| DOI |
10.1016/j.clim.2010.03.428
|
| PII |
S1521-6616(10)00528-0
|
| PMID |
20421177
|
| MeSH |
Administration, Oral
Animals
Arthritis, Rheumatoid / drug therapy*
CD4-Positive T-Lymphocytes / immunology
Cell Line
Cytokines / drug effects
Cytokines / metabolism
Dinoprostone / biosynthesis
Dinoprostone / metabolism
Disease Models, Animal
Female
Fingolimod Hydrochloride
Glucans
Humans
Immunosuppressive Agents / administration & dosage
Immunosuppressive Agents / therapeutic use*
Interleukin-4 / biosynthesis
Mice
Mice, Inbred Strains
Polysaccharides
Propylene Glycols / administration & dosage
Propylene Glycols / therapeutic use*
Specific Pathogen-Free Organisms
Sphingosine / administration & dosage
Sphingosine / analogs & derivatives*
Sphingosine / therapeutic use
Spleen / cytology
Thymus Gland / cytology
|
| IF |
3.368
|
| リソース情報 |
| ヒト・動物細胞 |
MH7A(RCB1512) |
