論文 - 詳細
| RRC ID | 72444 |
|---|---|
| 著者 | Tsunemi S, Iwasaki T, Kitano S, Imado T, Miyazawa K, Sano H. |
| タイトル | Effects of the novel immunosuppressant FTY720 in a murine rheumatoid arthritis model. |
| ジャーナル | Clin Immunol |
| Abstract |
We investigated the effects and mechanisms by which FTY720 (FTY) inhibits arthritis development in the SKG mouse rheumatoid arthritis (RA) model. FTY (1mg/kg/day) administration suppressed the progression of laminarin-induced arthritis in SKG mice. FTY treatment decreased IL-6 and TNF-alpha expression in synovial fibroblast cells and the number of inflammatory cells overall. Bone destruction was also suppressed by treatment with FTY. The numbers of CD4(+) and CD8(+) T cells were significantly increased in the thymus and decreased in the spleen in FTY-treated SKG mice. FTY enhanced IL-4 production by CD4(+) T cells stimulated by allogeneic spleen cells and inhibited prostaglandin E(2) (PGE(2)) production by a TNF-alpha-stimulated synovial fibroblast cell line. These results indicate that FTY can inhibit arthritis in SKG mice via sequestration of autoimmune CD4(+) T cells in the thymus, enhancement of Th2 immune responses, and inhibition of PGE(2) production by synovial cells. |
| 巻・号 | 136(2) |
| ページ | 197-204 |
| 公開日 | 2010-8-1 |
| DOI | 10.1016/j.clim.2010.03.428 |
| PII | S1521-6616(10)00528-0 |
| PMID | 20421177 |
| MeSH | Administration, Oral Animals Arthritis, Rheumatoid / drug therapy* CD4-Positive T-Lymphocytes / immunology Cell Line Cytokines / drug effects Cytokines / metabolism Dinoprostone / biosynthesis Dinoprostone / metabolism Disease Models, Animal Female Fingolimod Hydrochloride Glucans Humans Immunosuppressive Agents / administration & dosage Immunosuppressive Agents / therapeutic use* Interleukin-4 / biosynthesis Mice Mice, Inbred Strains Polysaccharides Propylene Glycols / administration & dosage Propylene Glycols / therapeutic use* Specific Pathogen-Free Organisms Sphingosine / administration & dosage Sphingosine / analogs & derivatives* Sphingosine / therapeutic use Spleen / cytology Thymus Gland / cytology |
| IF | 3.368 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | MH7A(RCB1512) |