RRC ID 72465
著者 Egli M, Leeners B, Kruger TH.
タイトル Prolactin secretion patterns: basic mechanisms and clinical implications for reproduction.
ジャーナル Reproduction
Abstract Prolactin (PRL) is one of the most versatile hormones in the mammalian body affecting reproductive, sexual, metabolic, immune, and other functions. It is therefore not surprising that the neural control of PRL secretion is complex, involving the coordinated actions of several hypothalamic nuclei. A plethora of experimental data exists on the hypothalamic control of hormone secretion under various physiological stimuli. There have been even mathematical models and computer studies published, which help to understand the complex hypothalamic-pituitary network. Nevertheless, the putative role of PRL for human reproduction still has to be clarified. Here, we review data on the underlying mechanisms controlling PRL secretion using both experimental and mathematical approaches. These investigations primarily focus on rhythmic secretion in rats during early pregnancy or pseudopregnancy, and they point to the important role of oxytocin as a crucial PRL-releasing factor. Recent data on human studies and their theoretical and clinical implications are reviewed as well. In particular, studies demonstrating a sustained PRL surge after sexual climax in males and females are presented, indicating possible implications for both sexual satiation and reproductive functions. Taking these data together, there is evidence for the hypothesis that the PRL surge induced by sexual activity, together with the altered PRL rhythmic pattern, is important for successful initialization of pregnancy not only in rodents but also possibly in humans. However, further investigations are needed to clarify such a role in humans.
巻・号 140(5)
ページ 643-54
公開日 2010-11-1
DOI 10.1530/REP-10-0033
PII REP-10-0033
PMID 20733016
MeSH Animals Female Humans Hypothalamo-Hypophyseal System / physiology* Male Oxytocin / physiology Pituitary-Adrenal System / physiology* Pregnancy Prolactin / metabolism* Prolactin / physiology Rats Reproduction / physiology* Sexual Behavior / physiology
IF 3.206
リソース情報
ヒト・動物細胞 KGN(RCB1154)