| RRC ID |
72502
|
| 著者 |
Han CK, Lee WF, Hsu CJ, Huang YL, Lin CY, Tsai CH, Huang CC, Fong YC, Wu MH, Liu JF, Tang CH.
|
| タイトル |
DPP4 reduces proinflammatory cytokine production in human rheumatoid arthritis synovial fibroblasts.
|
| ジャーナル |
J Cell Physiol
|
| Abstract |
Rheumatoid arthritis (RA) is an autoimmune disorder that is characterized by increasing levels of proinflammatory cytokines. The ubiquitous enzyme dipeptidyl peptidase-4 (DPP4, also known as CD26) regulates different immune disorders, although the effects of DPP4 in RA are uncertain. Here, we found lower levels of DPP4 in RA synovial tissues compared with normal tissues. DPP4 levels were also lower in a rat collagen-induced arthritis model than in control (healthy) rats. Overexpression of DPP4 or exogenous treatment of RA synovial fibroblasts with DPP4 reduced levels of proinflammatory interleukin (IL)-1β, IL-6, and IL-13, and increased anti-inflammatory IL-10 synthesis, while DPP4 inhibitors sitagliptin and vildagliptin increased proinflammatory cytokine production, indicating an enhanced risk of RA development. The evidence suggests that increasing DPP4 expression is a novel strategy for RA disease.
|
| 巻・号 |
236(12)
|
| ページ |
8060-8069
|
| 公開日 |
2021-12-1
|
| DOI |
10.1002/jcp.30494
|
| PMID |
34192347
|
| MeSH |
Animals
Arthritis, Rheumatoid / drug therapy*
Arthritis, Rheumatoid / metabolism
Cytokines / drug effects*
Cytokines / metabolism
Dipeptidyl Peptidase 4* / metabolism
Dipeptidyl Peptidase 4* / pharmacology
Fibroblasts / drug effects*
Fibroblasts / metabolism
Humans
Inflammation / drug therapy
Inflammation / metabolism
Synovial Membrane / drug effects
Synovial Membrane / metabolism
|
| IF |
5.546
|
| リソース情報 |
| ヒト・動物細胞 |
MH7A(RCB1512) |
