論文 - 詳細
| RRC ID | 72608 |
|---|---|
| 著者 | Kimura M, Naito H, Tojo T, Itaya-Hironaka A, Dohi Y, Yoshimura M, Nakagawara K, Takasawa S, Taniguchi S. |
| タイトル | REG Iα gene expression is linked with the poor prognosis of lung adenocarcinoma and squamous cell carcinoma patients via discrete mechanisms. |
| ジャーナル | Oncol Rep |
| Abstract |
The aim of the present study was to evaluate the effects of the REG Iα and REG Iβ genes on lung cancer cell lines, and thereafter, the expression of REG family genes (REG Iα, REG Iβ, REG III, HIP/PAP and REG IV) in lung cancer in relation to patient prognosis was evaluated. Lung adenocarcinoma (AD) and squamous cell carcinoma (SCC) cell lines expressing REG Iα or REG Iβ (HLC-1 REG Iα/Iβ and EBC-1 REG Iα/Iβ) were established, and cell number, cell invasive activity, and anchorage-independent cell growth were compared with these variables in the control cells. The expression levels of REG family genes were evaluated by real-time RT-PCR in surgically resected lung cancers, and disease-specific survival (DSS) curves were generated. The HLC-1 REG Iα/Iβ cell line showed significant increases in cell number and anchorage-independent cell growth compared with the control cells. EBC-1 REG Iα/Iβ cells showed significant increases in cell invasive activity and anchorage-independent cell growth as compared with the control cells. Except for the REG Iβ gene, expression of other REG family genes was observed in the surgically resected samples; however, DSS was significantly worse only in stage I patients who were positive for REG Iα expression than in patients who were negative for REG Iα expression. The effects of REG Iα on AD and SCC cells were different in the in vitro study, and a correlation between REG Iα expression and patient prognosis was noted in the in vivo study. Therefore, overexpression of REG Iα is a risk factor for poor prognosis caused by discrete mechanisms in AD and SCC patients. |
| 巻・号 | 30(6) |
| ページ | 2625-31 |
| 公開日 | 2013-12-1 |
| DOI | 10.3892/or.2013.2739 |
| PMID | 24065141 |
| PMC | PMC3840002 |
| MeSH | Adenocarcinoma / drug therapy Adenocarcinoma / genetics* Adenocarcinoma / pathology Adenocarcinoma of Lung Aged Biomarkers, Tumor / biosynthesis Biomarkers, Tumor / genetics Carcinoma, Squamous Cell / drug therapy Carcinoma, Squamous Cell / genetics* Carcinoma, Squamous Cell / pathology Disease-Free Survival Female Gene Expression Regulation, Neoplastic Humans Lithostathine / biosynthesis Lithostathine / genetics* Lung Neoplasms / drug therapy Lung Neoplasms / genetics* Lung Neoplasms / pathology Neoplasm Staging Pancreatitis-Associated Proteins Prognosis |
| IF | 3.417 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Wikipedia |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HLC-1(RCB0083) EBC-1(RCB1965) |