| RRC ID |
72619
|
| Author |
Nakagawa S, Matsuoka Y, Ichihara H, Yoshida H, Yoshida K, Ueoka R.
|
| Title |
Therapeutic effects of autologous lymphocytes activated with trastuzumab for xenograft mouse models of human breast cancer.
|
| Journal |
Biol Pharm Bull
|
| Abstract |
Trastuzumab (TTZ) is molecular targeted drug used for metastatic breast cancer patients overexpressing human epidermal growth factor receptor 2 (HER2). Therapeutic effects of lymphocytes activated with TTZ (TTZ-LAK) using xenograft mouse models of human breast cancer (MDA-MB-453) cells were examined in vivo. Remarkable reduction of tumor volume in a xenograft mouse models intravenously treated with TTZ-LAK cells after the subcutaneously inoculated of MDA-MB-453 cells was verified in vivo. The migration of TTZ-LAK cells in tumor of mouse models subcutaneously inoculated MDA-MB-453 cells was observed on the basis of histological analysis using immunostaining with CD-3. Induction of apoptosis in tumor of xenograft mice treated with TTZ-LAK cells was observed in micrographs using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) method. It was noteworthy that the therapeutic effects of TTZ-LAK cells along with apoptosis were obtained for xenograft mouse models of human breast tumor in vivo.
|
| Volume |
36(5)
|
| Pages |
861-5
|
| Published |
2013-1-1
|
| DOI |
10.1248/bpb.b12-01084
|
| PII |
DN/JST.JSTAGE/bpb/b12-01084
|
| PMID |
23649343
|
| MeSH |
Animals
Antibodies, Monoclonal, Humanized / administration & dosage*
Antineoplastic Agents / administration & dosage*
Apoptosis / drug effects
Breast Neoplasms / pathology
Breast Neoplasms / therapy*
Cell Line, Tumor
Female
Humans
Immunotherapy, Adoptive*
Killer Cells, Lymphokine-Activated*
Lymphocyte Activation
Mice
Mice, Inbred BALB C
Trastuzumab
Tumor Burden / drug effects
Xenograft Model Antitumor Assays
|
| IF |
1.863
|
| Resource |
| Human and Animal Cells |
MDA-MB-453(RCB1192) |
