Reference - Detail
| RRC ID | 72643 |
|---|---|
| Author | Hanaki Y, Miyoshi S, Sugiyama Y, Yanagita RC, Sato M. |
| Title | 12-O-Tetradecanoylphorbol 13-acetate promotes proliferation and epithelial-mesenchymal transition in HHUA cells cultured on collagen type I gel: A feasible model to find new therapies for endometrial diseases. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
HHUA endometrial adenocarcinoma cells aggregated into spheroids when cultured on collagen type I gels. 12-O-Tetradecanoylphorbol 13-acetate, a PKC activator, disassembled the spheroids through epithelial-mesenchymal transition and increased their proliferation rate, while inducing cell death under monolayer culture conditions. These unusual behaviors of endometrial epithelial cells with collagen fibers could be a target for the treatment of some endometrial diseases. |
| Volume | 86(10) |
| Pages | 1417-1422 |
| Published | 2022-9-23 |
| DOI | 10.1093/bbb/zbac136 |
| PII | 6668795 |
| PMID | 35973688 |
| MeSH | Acetates / metabolism Cell Proliferation Cells, Cultured Collagen Type I / metabolism Endometrium / metabolism Endometrium / pathology Epithelial-Mesenchymal Transition* Female Gels / metabolism Humans Tetradecanoylphorbol Acetate / pharmacology Uterine Diseases* |
| IF | 1.516 |
| Resource | |
| Human and Animal Cells | HHUA(RCB0658) |