| RRC ID |
72680
|
| Author |
Takamatsu G, Manome Y, Lee JS, Toyama K, Hayakawa T, Hara-Miyauchi C, Hasegawa-Ogawa M, Katagiri C, Kondo T, James Okano H, Matsushita M.
|
| Title |
Generation of four iPSC lines from a family harboring a 1p36-35 haplotype linked with bipolar disorder and recurrent depressive disorder: Three-generation patients and a healthy sibling.
|
| Journal |
Stem Cell Res
|
| Abstract |
Induced pluripotent stem cells (iPSCs) obtained from genetically characterized patients benefit the biological study of bipolar disorder (BD). Here, we present iPSC lines from three-generation patients with BD and recurrent depressive disorder (RDD) and a healthy control sibling in a family. All patients shared the specified haplotype in the 1p36-35, previously reported as the susceptibility locus of mood disorders. iPSCs were generated with the reprogramming factors OTC3/4, l-MYC, LIN28, SOX2, KLF4, and p53 shRNA through non-integrated episomal vectors. All iPSC lines strongly expressed pluripotency markers and proved the ability to differentiate into three germ lineages in vitro.
|
| Volume |
64
|
| Pages |
102915
|
| Published |
2022-10-1
|
| DOI |
10.1016/j.scr.2022.102915
|
| PII |
S1873-5061(22)00264-1
|
| PMID |
36166871
|
| MeSH |
Bipolar Disorder* / genetics
Depressive Disorder*
Haplotypes / genetics
Humans
Induced Pluripotent Stem Cells*
RNA, Small Interfering
Siblings
Tumor Suppressor Protein p53
|
| IF |
4.495
|
| Resource |
| Human and Animal Cells |
1383D6(HPS1006) |
