Reference - Detail
| RRC ID | 72680 |
|---|---|
| Author | Takamatsu G, Manome Y, Lee JS, Toyama K, Hayakawa T, Hara-Miyauchi C, Hasegawa-Ogawa M, Katagiri C, Kondo T, James Okano H, Matsushita M. |
| Title | Generation of four iPSC lines from a family harboring a 1p36-35 haplotype linked with bipolar disorder and recurrent depressive disorder: Three-generation patients and a healthy sibling. |
| Journal | Stem Cell Res |
| Abstract |
Induced pluripotent stem cells (iPSCs) obtained from genetically characterized patients benefit the biological study of bipolar disorder (BD). Here, we present iPSC lines from three-generation patients with BD and recurrent depressive disorder (RDD) and a healthy control sibling in a family. All patients shared the specified haplotype in the 1p36-35, previously reported as the susceptibility locus of mood disorders. iPSCs were generated with the reprogramming factors OTC3/4, l-MYC, LIN28, SOX2, KLF4, and p53 shRNA through non-integrated episomal vectors. All iPSC lines strongly expressed pluripotency markers and proved the ability to differentiate into three germ lineages in vitro. |
| Volume | 64 |
| Pages | 102915 |
| Published | 2022-10-1 |
| DOI | 10.1016/j.scr.2022.102915 |
| PII | S1873-5061(22)00264-1 |
| PMID | 36166871 |
| MeSH | Bipolar Disorder* / genetics Depressive Disorder* Haplotypes / genetics Humans Induced Pluripotent Stem Cells* RNA, Small Interfering Siblings Tumor Suppressor Protein p53 |
| IF | 4.495 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | 1383D6(HPS1006) |