論文 - 詳細
| RRC ID | 72764 |
|---|---|
| 著者 | Sánchez CA, Li H, Phelps KL, Zambrana-Torrelio C, Wang LF, Zhou P, Shi ZL, Olival KJ, Daszak P. |
| タイトル | A strategy to assess spillover risk of bat SARS-related coronaviruses in Southeast Asia. |
| ジャーナル | Nat Commun |
| Abstract |
Emerging diseases caused by coronaviruses of likely bat origin (e.g., SARS, MERS, SADS, COVID-19) have disrupted global health and economies for two decades. Evidence suggests that some bat SARS-related coronaviruses (SARSr-CoVs) could infect people directly, and that their spillover is more frequent than previously recognized. Each zoonotic spillover of a novel virus represents an opportunity for evolutionary adaptation and further spread; therefore, quantifying the extent of this spillover may help target prevention programs. We derive current range distributions for known bat SARSr-CoV hosts and quantify their overlap with human populations. We then use probabilistic risk assessment and data on human-bat contact, human viral seroprevalence, and antibody duration to estimate that a median of 66,280 people (95% CI: 65,351-67,131) are infected with SARSr-CoVs annually in Southeast Asia. These data on the geography and scale of spillover can be used to target surveillance and prevention programs for potential future bat-CoV emergence. |
| 巻・号 | 13(1) |
| ページ | 4380 |
| 公開日 | 2022-8-9 |
| DOI | 10.1038/s41467-022-31860-w |
| PII | 10.1038/s41467-022-31860-w |
| PMID | 35945197 |
| PMC | PMC9363439 |
| MeSH | Animals Asia, Southeastern / epidemiology COVID-19* Chiroptera* Evolution, Molecular Humans Phylogeny Seroepidemiologic Studies Severe acute respiratory syndrome-related coronavirus* |
| IF | 12.121 |
| リソース情報 | |
| GBIF | Long-term fauna and flora records of the experimental forests of the Forest Research Station of Hokkaido University, Japan Mammal specimens of Okinawa Prefectural Museum & Art Museum Mammalian Specimens of the Yamagata Prefectural Museum Mammal specimens of Ryukyu University Museum (Fujukan) Vertebrate specimens of Kumamoto City Museum Mammalians Specimens of Akita Prefectural Museum Ibaraki Nature Museum, Mammals collection Mammal collection of National Museum of Nature and Science Mammal specimen database of Kanagawa Prefectural Museum of Natural History Gunma Museum of Natural History, Mammal Specimen Mammal specimens of Takatsuki Nature Museum (Aquapia Akutagawa) Mammal collection of Biodiversity Center of Japan, Ministry of the Environment (BDCJ) |