Reference - Detail
| RRC ID | 72822 |
|---|---|
| Author | Kwon OS, Kim D, Kim H, Lee YJ, Lee HS, Sim CJ, Oh DC, Lee SK, Oh KB, Shin J. |
| Title | Bromopyrrole Alkaloids from the Sponge Agelas kosrae. |
| Journal | Mar Drugs |
| Abstract |
Two new sceptrin derivatives (1,2) and eight structurally-related known bromopyrrole-bearing alkaloids were isolated from the tropical sponge Agelas kosrae. By a combination of spectroscopic methods, the new compounds, designated dioxysceptrin (1) and ageleste C (2), were determined to be structural analogs of each other that differ at the imidazole moiety. Dioxysceptrin was also found to exist as a mixture of α-amido epimers. The sceptrin alkaloids exhibited weak cytotoxicity against cancer cells. Compounds 1 and 2 also moderately exhibited anti-angiogenic and isocitrate lyase-inhibitory activities, respectively. |
| Volume | 16(12) |
| Published | 2018-12-17 |
| DOI | 10.3390/md16120513 |
| PII | md16120513 |
| PMID | 30563015 |
| PMC | PMC6316234 |
| MeSH | Agelas / chemistry* Alkaloids / chemistry Alkaloids / isolation & purification Alkaloids / pharmacology* Angiogenesis Inhibitors / chemistry Angiogenesis Inhibitors / isolation & purification Angiogenesis Inhibitors / pharmacology Animals Antineoplastic Agents / chemistry Antineoplastic Agents / isolation & purification Antineoplastic Agents / pharmacology Biological Products / isolation & purification Biological Products / pharmacology* Cell Line, Tumor Drug Screening Assays, Antitumor Enzyme Assays Human Umbilical Vein Endothelial Cells Humans Isocitrate Lyase / antagonists & inhibitors Pyrroles / chemistry Pyrroles / isolation & purification Pyrroles / pharmacology* Stereoisomerism |
| IF | 4.073 |
| Resource | |
| Pathogenic eukaryotic microorganisms | Trichophyton mentagrophytes IFM 40997 |